Nycomed Pharma As

Takeda As

Takeda Nycomed As

Nycomed Danmark Aps

Jan Yngvar Piene

Dina Dogger Schmidt

Kjell Tomas Lunde

Jimmy Hirschsprung Schlyter

Calcium-containing compounds have been at least partly film-coated and/or granulated with a water-soluble substance and a water-soluble polymeric substance and use of such coated compounds in pharmaceutical compositions. The at least partly film-coated and/or granulated calcium-containing compounds have proved suitable for the preparation of tablets having a very high load of elemental calcium and a conveniently small size. A drug load of about 96% or more is obtained in tablets of the invention that have sufficient mechanical and organoleptic properties.

Film-coated and/or granulated calcium-containing compounds and use therof in pharmaceutical compositions

Film-coated and/or granulated calcium-containing compounds and use thereof in pharmaceutical compositions

A process for the preparation of an orally administrable calcium composition comprising the steps of: (i) obtaining a physiologically tolerable particulate calcium compound having a mean particle size in the range of 3 to 40 &#x3bc;m, having a crystalline structure and having a surface area of 0.1 to 1.2 m/g; (ii) mixing the calcium compound with a water-soluble diluent and an aqueous solution of a water soluble binder in a fluid bed granulation apparatus and dying the resulting mixture to produce a first granulate; (iii) optionally mixing the first granulate with one or more further components to produce a second granulate; and (iv) optionally compressing the first or second granulate to form tablets.

Process for preparing oral calcium compositions

A process for the preparation of an orally administrable calcium composition comprising the steps of: (i) obtaining a physiologically tolerable particulate calcium compound having a mean particle size in the range 3 to 40 &#x3bc;m, having a crystalline structure and having a surface area of 0.1 to 1.2 m/g; (ii) mixing the calcium compound with a water-soluble diluent and an aqueous solution of a water soluble binder in a fluid bed granulation apparatus and drying the resulting mixture to produce a first granulate; (iii) optionally mixing the first granulate with one or more further components to produce a second granulate; and (iv) optionally compressing the first or second granulate to form tablets.

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Asker, Norway

Jan Yngvar Piene