Ge Healthcare Limited

Ge Healthcare As

Medi-physics, Inc.

Amersham Health As

Jan Wolber

Klaes Golman

Bastiaan Driehuys

Rolf Servin

Jan Henrik Ardenkjaer-Larsen

Margaret Hall

Claudio Marelli

Mark Howard

Mikkel Jacob Thaning

Graham John Cotton

Haukur Johannesson

Peter Knox

Nigel Bosworth

Jan-Henrik Ardenkjaer-Larsen

Sven Mansson

Herbert Baumann

Oskar H E Axelsson

Neil Cook

Mark Rosser

Jan Jenrik Ardenkjaer-Larsen

Sven Mansoon

Mathilde H Lerche

Maurice Goldman

Mike Looker

Scott Lagona

Albie Santos

Mikkel Thaning

Systems and methods for tracking and management of a distributed ledger including information for a batch of radiopharmaceutical material are disclosed. Certain examples provide a computer-implemented method of managing radiopharmaceutical material including tracking, using at least one processor, a status of a batch of radiopharmaceutical material, the status to include a type, a quantity, and a timestamp associated with the batch of radiopharmaceutical material; generating a record in a first copy of a distributed ledger using the type, quantity, and timestamp associated with the batch of radiopharmaceutical material; updating the record based on at least one of usage of the batch of radiopharmaceutical material, resale of at least a portion of the batch of radiopharmaceutical material, and decay of the batch of radiopharmaceutical material; and sharing the record with a second copy of the distributed ledger.

Apparatus, non-transitory computer-readable storage medium, and computer-implemented method for distributed ledger management of nuclear medicine products

A method of imaging to permit calculation of left:right striatum uptake ratios is provided, and the degree of asymmetry used to assist in the diagnosis of neurological diseases. Also provided are a method of diagnosis, method of patient selection, and method of therapy monitoring using the imaging method, and software tools for use in the method.

Imaging neurological disease

The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarization methods offering enhanced sensitivity of detection over conventional NMR for studying the fate of a test compound in a biological system. The methods are particularly suitable for studying metabolism and toxicity of drugs. The resulting NMR sensitivity increase is advantageous in two key aspects of NMR detection: test compounds can be detected at lower concentrations and substantial time saving can be achieved in cases where extensive averaging is conventionally employed to increase the signal to noise ratio of the corresponding NMR spectra. The methods can be used for studios that were not practical or not possible using conventional NMR.

Method for investigating the fate of a test compound or the stateof a biological system by means of NMR of hyperpolarised NMR active nuclei

In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarizedXe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue; (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a respiratory, cardiopulmonary disorder or disease such as chronic heart failure, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.

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The invention relates to NMR-based methods comprising hyperpolarised ligands or targets for use in NMR-based assays.

NMR-based methods for detecting ligands, where the ligand or target are hyperpolarized and the NMR-spectrum is compared with a reference spectrum of the ligand or target

The present invention relates to methods of performing Nuclear Magnetic Resonance (NMR) spectroscopy adapted for a hyperpolarized sample. The methods comprise the steps of hyperpolarizing a sample using DNP, wherein at least a portion of the NMR active nuclei receives hyperpolarization; performing NMR spectroscopy on the sample with the use of sequences of rf-pulses, wherein the pulse sequences comprises at least two rf-pulses, either on the same nuclei or on different nuclei, and wherein the pulse sequence is adapted for a hyperpolarized sample; and analyzing at least two of the NMR spectra to obtain a characterization of the sample, or to obtain an interim result to be used in the NMR spectroscopy step.

Multidimensional NMR spectroscopy of a hyperpolarized sample

Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe

The present invention relates to devices and method for melting solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cupin a strong magnetic field in a polarising meansin a cryostatand then melted inside the cryostatby melting means such as a laserconnected by an optical fibreto the interior of the cryostat.

Methods and devices for hyperpolarising and melting NMR samples in a cryostat

Growing community of inventors

Malmo, Sweden

Jan Wolber