Duphar International Research Bv

U.S. Philips Corporation

Jan Van Dijk

Johannes M Zwagemakers

Volkert Claassen

Jenkin E Davies

Ineke Van Wijngaarden

Wilhelmus J Josquin

Johannes E Steenhuisen

Johan K Van Dasler

Jenkins Eric Davies

The invention relates to a method of improving the growth and the feed efficiency and of increasing the muscle/fat ratio of agricultural domestic animals, in particular bovine animals and sheep, by administering to the animals a composition which comprises as an active substance a compound of the general formula ##STR1## wherein: R.sub.1 is a phenylalkyl group the alkyl group of which comprises 1-3 carbon atoms and the phenyl group of which may be substituted with one or more substituents selected from the group consisting of hydroxy, methoxy, fluoro and methylsulphonylamino, or wherein

Method of increasing the muscle/fat ratio in agricultural domestic

A first device region (20) of one conductivity type is provided adjacent one major surface (11) of a semiconductor body (10). A layer (30) doped with impurities of the opposite conductivity type is provided on the one major surface (11) for forming an extrinsic subsidiary region (41) of a second device region (40) of the opposite conductivity type. An opening (31) is formed through the doped layer (30). Impurities for forming a coupling region (43) of the opposite conductivity type are introduced through the opening (31) prior to defining an insulating first portion (50) on the side wall (32) of the doped layer (30) to form a first window (80). Impurities for forming an intrinsic subsidiary region (42) of the second device region (40) are introduced through the first window (80). A second portion (60) is then defined on the insulating first portion (50) to form a smaller second window (90), and impurities for forming a third device region (70) through the second window (90) so that the extrinsic subsidiary region (41) and third device region are well spaced whilst the coupling region (43) enables good connection between the extrinsic and intrinsic subsidiary regions (41 and 42).

Method of manufacturing a bipolar transistor

The invention relates to new spasmolytically active tertiary amine derivatives and the salts thereof, of the formula (1) ##STR1## wherein the symbols have the following meanings: .circle.A is phenyl, or a 5- or 6-membered aromatic group containing 1 or 2 of the following hetero atoms: oxygen and/or sulphur and/or nitrogen;

Spasmolytically active tertiary amine derivatives

The invention relates to a hypodermic syringe comprising a cartridge having connected thereto an injection needle, a medicament holder closed by means of a piercible stopper, and a telescopic assembly which detachably connects the cartridge and the holder. The part of the injection needle extending within the telescopic assembly is surrounded entirely by a sheath of a flexible material the closed end of which bears against or is present at a short distance from the stopper of the medicament holder.

Hypodermic syringe having a telescopic assembly between cartridge and

The invention relates to a disposable syringe comprising a barrel which has on its front end a needle connection with injection needle and needle guard. The syringe is provided with a sealing member for the needle guard which consists of a sleeve of shrinkable plastic material. The sleeve is shrunk on one side around the needle connection and/or around the barrel or a front part of the barrel, and on the other side around a part of the needle guard adjoining the needle connection.

Disposable hypodermic syringe

There is disclosed pharmaceutical preparations and a method of using same in the treatment of inflammation and/or pain, e.g., treating rheumatic affections, with novel substituted alkylidene-aminooxyalkyl carboxylic acid esters.

Novel basic substituted-alkylidenamino-oxyalkyl-carboxylic acid esters

Novel substituted-alkylidene-aminooxyalkylcarboxylic acid esters of the formula I and their acid addition salts have a strong antiinflammatory and a potent analgetic activity and a low toxicity. The substances may be used for treating rheumatic affections. They may be synthetized and formulated into preparations by known methods.

Novel basic substituted-alkylidenamino-oxylalkyl-carboxylic-acid esters

Amino ethyl alkyl phenone oximes to treat depression.

Compounds having pharmacological properties

Certain nuclear substituted benzylidene amino oxyalkyl carboxylic acids esters, amides and salts thereof have been found to have a strong anti-inflammatory activity and a potent analgetic activity. In addition, some of the compounds have an activity against Rhino virus. An example is [(4-chlorobenzylideneamino)oxy] acetic acid.

Novel benzylidene amini-oxyalkyl carboxylic acids and carboxylic acid

Two amino-ethyl methylthio substituted alkylenephenone oximes have been found to exhibit antidepressive activities. The two compounds are O-(2-amino-ethyl)-4'-methylthioacetophenone oxime and O-(2-amino-ethyl)-4'-methylthiohexanophenone oxime.

Novel benzylidene amino-oxyalkyl carboxylic acids and carboxylic acid

The novel compounds of the formula 1 and their acid addition salts have a strong antiinflammatory and a potent analgetic activity and a low toxicity. The substances may be used for treating rheumatic affections. They may be synthetized and formulated into preparations by known methods.

Novel basic substituted-alkylidenamino-oxylalkylcarboxylic-acid esters

The invention relates to new compounds of formula I ##SPC1## and salts thereof with pharmaceutically acceptable acids, in which formula all the substituents may be hydrogen, while R.sub.1 and R.sub.2 may furthermore be a methyl group, R.sub.3 an alkyl group, an alkoxy-alkylene group, an alkylthioalkylene group, an alkylsulphoxyalkylene group or an alkylsulphonalkylene group having up to 8 carbon atoms or a benzyl group, and R.sub.4, R.sub.5 and R.sub.6 a halogen atom, an alkyl group, an alkoxy group or an alkylthio group having up to 6 carbon atoms, a benzyloxy group, --OH, --NH.sub.2, a mono- or dialkylamino group, in which the alkyl group(s) contain(s) 1 or 2 carbon atoms, --CN or --CF.sub.3, and two of the substituents R.sub.4, R.sub.5 and R.sub.6 may each represent a metanitro group or together a trimethylene group, a tetramethylene group, a methylene dioxy group, an ethylene dioxy group, a benzo group, a pyridino group, an indeno-1,2-, a 1,4-benzthiazino-2,3 group or a 1,4-benzoxthiino-2,3 group, with the exception of the HCl salt of the compound in which R.sub.5 and R.sub.6 each represent an orthochlorine atom and R.sub. 1, R.sub.2, R.sub.3 and R.sub.4 each represent hydrogen.

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Weesp, Netherlands

Jan Van Dijk