Nederlandse Organisatie Voor Toegepast-natuurwetenschappelijk Onderzoek Tno

Bg Medicine, Inc.

Jan Van Der Greef

Noubar Boghos Afeyan

Aram S Adourian

Matej Oresic

Eric K Neumann

Albert Tas

Elwin Robbert Verheij

Jacibus Thomas Wilhelmus Elisabeth Vogels

Frederick E Regnier

Florian Wulfert

The present invention provides methods and systems for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components of a plurality of biological samples. Preferably, the method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation.

Method and system for profiling biological systems

Method and system for processing and evaluating data from combination chromatographic and mass spectrometric data. The methods and system comprise data smoothing and determination of an quality factor for a chromatogram of a data set based on a determined entropy value. In one embodiment, the methods and system further comprise data baseline correction prior to entropy value determination. In a further embodiment, a correlation is determined between chromatograms processed according to the invention and one or more chromatograms of one or more data sets. Preferably, said correlation is performed using a multivariate analysis.

Method and system for identifying and quantifying chemical components of a mixture

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Driebergen-Rijsenburg, Netherlands

Jan Van Der Greef