Maxim Pharmaceuticals, Inc.

Jan Urban Kristoffer Hellstrand

Svante Hermod Hermodsson

A method for providing activated natural killer (NK) cells comprising the steps of administering to a population of cells which includes lymphocytes and monocytes, an effective amount of an NK cell activating cytokine or a NK cell activating flavonoid, wherein said NK cell activating cytokine is not IL-2 or IFN-&agr;; and administering a compound effective to inhibit the production or release of hydrogen peroxide selected from the group consisting of histamine, other H receptor agonists, and serotonin.

Enhanced activation of natural killer cells using an NK cell activator and a hydrogen peroxide scavenger or inhibitor

A method for treating neoplastic disease comprising the steps of: administering to a patient receiving radiation therapy or chemotherapy, an effective amount of an NK cell activating cytokine or an NK cell activating flavonoid, wherein said NK cell activating cytokine is not IL-2 or IFN-&agr;; and administering to the patient a compound effective to inhibit the production or release of intracellular hydrogen peroxide selected from the group consisting of histamine, other H,receptor agonists, and serotonin.

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Gothenburg, Sweden

Jan Urban Kristoffer Hellstrand