Astra Pharmaceutical Production Aktiebolag

Astra Lakemedel Aktieboag

Jan U Stenhede

Edib Jakupovic

Lars Berhil Stenmark

Per Gustaf Nyqvist

Rolf P Svensson

Roy T Sourander

Ulf A Kjellberg

A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives characterized in reaction of a corresponding 16,17-acetonide with an aldehyde or ketone in (a) hydrocarbon solvent wherein the solubility of the pregnane derivative is less than 1 mg/l or in a halogenated hydrocarbon solvent together with a hydrohalogen acid or an organic sulphonic acid as catalyst and in the presence of small grains of an insert material in the reaction medium or (b) a halogenated hydrocarbon solvent together with a hydrohalogen acid an organic sulphonic acid as catalyst and in the presence of an epimeric distribution modifier.

Method of controlling the epimeric distribution in the preparation of

A new process for the stabilization of bacampicillin hydrochloride against degradation by humidity characterized by the incorporation of between 3 to 9% by weight of straight-chain alkanes, alkenes, fatty acids, alcohols, and esters of fatty acids and alcohols with molecular weights between 144 and 350, which may be carried out in one step together with wetmassing for granulation.

Process for stabilization of bacampicillin hydrochloride

Growing community of inventors

Sodertalje, Sweden

Jan U Stenhede