Smart Brain S.r.o.

Biotechnologicky Ustav Av Cr, V.v.i.

Springtide Ventures S.r.o.

Mitotax S.r.o.

Ustav Molekularni Genetiky Av Cr, V.v.i.

Biotechnology Ustav Av Cr, V.v.i.

Kkcg Ag

Institute of Biotechnology Cas, V.v.i.

Neuzil, Jiri

Jan Stursa

Lukas Werner

Jiri Neuzil

Sona Hubackova

Michal Dvorak

Marta Dvorakova

Vit Karafiat

Lucie Janeckova

Kristyna Blazkova

Lukás Werner

Jirí Neuzil

The present invention relates to compounds of general formula (I) in particular for use in the treatment of senescence-related diseases, such as idiopathic pulmonary fibrosis, sarcopenia, diabetes, obesity, osteoarthritis, chronic inflammations, glaucoma, cataracts, radiation-induced oral mucosis, renal transplantation, prostatic hyperplasia. 

Method for treatment of senescence-related disorders

The present invention relates to 1-acyl-lysophosphatidyl derivatives of general formula I; in which R is C4 to C30 aliphatic hydrocarbyl chain, R1 is selected from H or C1 to C10 alkyl, preferably C1 to C6 alkyl, R2 is selected from H, C10 to C30 acyl or C1 to C10 alkyl, preferably C1 to C6 alkyl, and R3, when present, is selected from H or C1 to C10 alkyl, preferably C1 to C6 alkyl. These derivatives are intended for the treatment of cancer, in particular melanoma, hepatocarcinoma or GIT carcinomas.

Phospholipid derivatives and their use as medicaments

Compounds for treatment of senescence-related disorders

The subject of the invention are new mitochondrially targeted E/Z isomers of aliphatic triphenylphosphonium derivatives of tamoxifen where the aliphatic chain is alkyl or alkenyl, and their corresponding tertiary amine salts and/or their mixture (MitoTAX). Alkyl triphenylphosphonium derivatives of tamoxifen have the general formula (I), where n=8 to 12 and where Z is selected from the group of organic salts or inorganic salts. Alkenyl triphenylphosphonium derivatives of tamoxifen have the general formula IA, where n=6 to 10 and where Z has the above mentioned meaning. These compounds are applicable for the treatment of neoplastic disease, especially those with high HER2 protein levels. The drug for the treatment of neoplastic diseases according to the invention contains at least one E/Z isomer of aliphatic triphenylphosphonium derivatives of tamoxifen of the general formula (I) and/or IA or their corresponding salts of tertiary amine.

Tamoxifen derivatives for treatment of neoplastic diseases, especially with high HER2 protein level

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Prague, Czechia

Jan Stursa