Bayer Pharma Aktiengesellschaft

Jan Stampfuß

Susanne Röhrig

Karl-Heinz Schlemmer

Adrian Tersteegen

Alexander Hillisch

Stefan Heitmeier

Jens Ackerstaff

Henrik Teller

Martina Victoria Schmidt

Eloisa Jimenez Nunez

Dieter Lang

Joachim Schuhmacher

Daniel Meibom

Yolanda Cancho Grande

Johannes Köbberling

Michael Sperzel

Nils Burkhardt

Christian Stegmann

Manuel Ellermann

Tom Kinzel

Maria Köllnberger

Kristin Beyer

Matthias Werner

Jorma Haßfeld

Katharina Meier

Pascal Ellerbrock

Gaelle Valot

Imke Meyer

Jörg Heiermann

Willem Jan Hengeveld

Eloisa Jimenez Núnez

Eloisa Jimenez-Nunez

The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

Substituted oxopyridine derivatives

The invention relates to substituted oxopyridine derivatives and to processes for preparation thereof, and also to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially of cardiovascular disorders, preferably thrombotic or thromboembolic disorders, and oedemas, and also ophthalmic disorders.

The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

Piperidinylpyrazolopyrimidinones and their use

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Düsseldorf, Germany

Jan Stampfuß