Dsm IP Assets B.v.

Jan Schütz

Werner Bonrath

Thomas Netscher

Christof Wehrli

Jonathan Alan Medlock

Reinhard Karge

Ulla Letinois

Bettina Wüstenberg

Wolfgang Hölderich

Verena Ritzerfeld

Bernhard Markus Ernst Russbüldt

Erhard Henning Fleischhauer

The present invention relates to an improved process for the production of 4-alkanoyloxy-2-methylbutanoic acid, as well as to the use of such compounds in organic syntheses, especially in processes forming intermediates (building blocks) for the synthesis of organic compounds comprising isoprene (isoterpene) units, such as &#x3b2;-carotene or other carotenoids (e.g. canthaxanthin, zeaxanthin or astaxanthin) or as vitamin E or vitamin A as well as other structurally similar compounds.

Process for the production of 4-alkanoyloxy-2-methylbutanoic acid

The present invention relates to compounds of formula (I) wherein Rsignifies a C-Calkyl moiety or a Cto Calkenyl moiety, to their process of production as well as to their use in organic synthesis, especially as intermediates (building blocks) in the synthesis of vitamin A or &#x3b2;-carotene or derivatives thereof, or other carotenoids, e.g. canthaxanthin, astaxanthin or zeaxanthin, preferably vitamin A. 

Intermediates for the vitamin A and &#x3b2;-carotene synthesis

The present invention relates to new organic compounds, to their synthesis as well as to their use in organic synthesis, especially in processes forming intermediates (building blocks) for the synthesis of vitamin A or &#x3b2;-carotene or other carotenoids.

Acid chloride

The present invention relates to an improved process for the production of 1,3,3-trimethyl-2-(3-methylpent-2-en-4-ynyl)cyclohex-1-ene, highly enriched in the Z-isomer, and the use of such compounds in organic syntheses, especially in processes forming intermediates (building blocks) the synthesis of vitamin A or &#x3b2;-carotene or other carotenoids, e.g. canthaxanthin, astaxanthin or zeaxanthin.

Process for the production of 1,3,3-trimethyl-2-(3-methylpent-2-en-4-ynyl)cyclohex-1-ene

Use of pure lanthanum oxide which is obtained by calcination of oxygen-containing lanthanum salts at temperatures of at least 700&#xb0; C. as heterogeneous catalyst in the aldol condensation of citral and acetone to give pseudoionone, and process for the preparation of pseudoionone by aldol condensation of citral and acetone in the liquid phase using pure lanthanum oxide.

Process for preparing pseudoionone

The present invention relates to a new way for the production of 4-acetoxy-2-methyl-butanal, wherein a non-acidic catalytic system is used.

Preparation of 4-acetoxy-2-methylbutanal by catalytic carbon carbon double bond hydrogenation

The present invention is directed to a process for the manufacture of 2,3,5-trimethyl-hydro-p-benzoquinone comprising the following steps: a) hydrogenating 2,6-dimethyl-p-benzoquinone with hydrogen in the presence of a hydrogenation catalyst in an organic solvent to obtain 2,6-dimethyl-hydro-p-benzoquinone; b) reacting 2,6-dimethyl-hydro-p-benzoquinone with a secondary amine and formal-dehyde in an organic solvent to obtain 2,6-dimethyl-3-(N,N-disubstituted aminomethyl)-hydro-p-benzoquinone; c) reacting 2,6-dimethyl-3-(N,N-disubstituted aminomethyl)-hydro-p-benzoquinone with hydrogen in the presence of a hydrogenolysis catalyst in an organic solvent to obtain 2,3,5-trimethylhydro-p-benzoquinone; wherein the organic solvent in all steps a), b) and c) is independently selected from the group consisting of methyl tert.-butyl ether, ethyl tert.-butyl ether, methyl tert.-amyl ether, methoxycyclopentane and any mixtures thereof. Preferably the organic solvent used in all steps a), b) and c) is the same.

Process for the manufacture of TMHQ

A process for the preparation of 1-ethynyl-3,3-dimethylcyclohexan-1-ol from dimedone by a reaction sequence of reduction and ethynylation and its further transformation into green ketone.

Synthesis of green ketone intermediate

A process for the preparation of 5-substituted 4-amino-2-methylpyrimidines of the formula (I) wherein R is CONHor CN, and of acid addition salts thereof, characterized in that a compound of formula HN CH&#x2550;C(R)CN (II) is reacted with acetimidic acid methyl ester or an acid addition salt thereof and that, if desired, a compound of formula (I) is transferred into an acid addition salt, and the transformation of a compound of formula (II) wherein R is CONHinto a compound of formula (II) wherein R is CN by treatment with POCI. 

Process for the preparation of pyrimidine derivatives

A new process for extracting and purifying glucosinolates from plant material, preferably broccoli sprouts or seeds is described. An alcoholic extract is adsorbed onto a basic resin and eluted with ammonia. Optionally, the alcoholic extract is passed through an ion-exchange column containing acidic resin prior to the adsorption/elution step.

Growing community of inventors

Basel, Switzerland

Jan Schütz