Entasis Therapeutics, Inc.

Jan Romero

Ruben Alberto Tommasi

Thomas Francois Durand-Reville

Xiaoyun Wu

Janelle Comita-Prevoir

Jing Zhang

Jeroen Cunera Verheijen

Frank Wu

Satenig Guler

John O'Donnell

Camilo Velez-Vega

Lise Gauthier

Mark Sylvester

Gregory S Basarab

Bill Moss

Ruben Tommasi

Provided herein are antibacterial compounds represented by Formula I, or a pharmaceutically acceptable salt thereof, wherein X, Y, R, R, and Rare as defined herein. Also provided are pharmaceutical compositions comprising the compounds of Formula I. 

Compounds and methods for treating bacterial infections

The present invention is directed to compounds which are beta-lactamase inhibitors. The compounds and their pharmaceutically acceptable salts are useful in combination with beta-lactam antibiotics, for the treatment of bacterial infections, including infections caused by drug resistant organisms, including multi-drug resistant organisms. The present invention includes compounds according to Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of R, R, R, R, Rand Rare described herein. 

Beta-lactamase inhibitor compounds

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Arlington, MA, United States of America

Jan Romero