Hoechst Aktiengesellschaft

Aventis Pharma Deutschland, Gmbh

Hoechst Marion Roussel Deutschland Gmbh

Hoeschst Aktiengesellschaft

Jan-Robert Schwark

Andreas Gerhard Weichert

Heinz-Werner Kleemann

Wolfgang Scholz

Udo Albus

Hans-Jochen Lang

Hans Jochen Lang

Joachim Brendel

Hans-Willi Jansen

Sabine Faber

Stefan Petry

Peter Crause

Bansi Lal

Klaus Wirth

Heinrich Christian Englert

Uwe Heinelt

Werner Kramer

Alfons Enhsen

Ravindra Dattatraya Gupte

Anil Vasantrao Ghate

Arun Kumar Jain

Rao Venkata Vadlamudi

Eugene Falk

Nirogi Venkata Ramakrishna

Substituted norbornylamino derivatives, processes for their preparation, their use as medicaments or diagnostics, and a medicament comprising them

Monoacyl-substituted guanidines, a process for their preparation, their use as a medicament or diagnostic aid, and pharmaceutical compositions containing them

The invention relates to compounds of formula (I) in which the symbols have the meanings given in the claims. Said compounds are inhibitors of the sodium-dependent bicarbonate/chloride ion exchanger which can be used as medicines for the prophylaxis or treatment of a wide range of diseases, for example the treatment and/or prophylaxis of myocardial infarction, angina pectoris, diseases caused by ischaemia, impaired respiration, cardiac ischaemia, ischaemia of the peripheral and central nervous system and stroke, ischaemia of the peripheral organs and limbs and diseases in which cell proliferation is a primary or secondary cause, in the treatment of shock, during surgical interventions and organ transplants or for preserving and storing transplants to be used in surgical interventions.

Substituted sulphonyl cyanamides, method for producing same and their use as medicament

Fluorophenyl-substituted alkenylcarboxylic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them

Five-membered heterocycles having biphenylsulfonyl substitution, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them

Diacyl-substituted guanidines, a process for their preparation, their use as medicine or diagnostic aid, and medicine containing them

Biphenylsulfonyl-substituted imidazole derivatives, their preparation process, their use as a drug or diagnostic agent and drug containing them

Biphenylsulfonyl cyanamides, method for the production thereof and their utilization as a medicament

Imidazole derivatives with biphenylsulfonyl substitution method for preparing them and their use as a drug or diagnostic agent

Five-membered heterocycles having biphenylsulfonyl substitution, with sulfonylcyanamide side chain, compositions containing them, and methods of using them

Ortho-substituted benzoylguanidines of the formula I

Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them

Substituted phenylalkenoylguanidines, processes for their preparation, uses as medicaments or diagnostics, and medicaments containing them are described. The invention relates to substituted phenylalkenoylguanidines and their pharmaceutically tolerable salts and physiologically functional derivatives of the formula ##STR1## in which the radicals have the meanings indicated, and their physiologically tolerable salts and processes for their preparation. The compounds are suitable as medicaments for the prophylaxis or treatment of gallstones.

Substituted phenylalkenoylguanidines, process for their preparation, and

There are described benzoylguanidines of the formula I ##STR1## where R(1) is R(4)--SO.sub.m, R(5)R(6)N--SO.sub.2 --; O.sub.p --(CH.sub.2).sub.q --(CF.sub.2).sub.r --CF.sub.3 ; --SR(10), --OR(10) or --CR(10)R(11)R(12); R(2) is --(CH.sub.2).sub.u --(CF.sub.2).sub.t --CF.sub.3 ; R(3) is hydrogen or independently defined as R(1); and their pharmaceutically tolerable salts. They are obtained by reaction of a compound of the formula II ##STR2## with guanidine. They are compounds of outstanding activity on the cardiovascular system.

4-fluoroalkyl-substituted benzoylguanidines, process for their

Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them. Ortho-substituted benzoylguanidines of the formula I ##STR1## in which R(1) to R(4) have the meanings given in the claims, are suitable, as antiarrhythmic pharmaceuticals having a cardioprotective component, for the prophylaxis and treatment of infarction and for the treatment of angina pectoris. They also inhibit, in a preventive manner, the pathophysiological processes associated with the genesis of ischemically induced damage, in particular associated with the triggering of ischemically induced cardiac arrhythmias.

Ortho-substituted benzoylguanidines, process for their preparation,

Substituted bicyclic heteroaroylguanidines, a process for their preparation, their use as a medicament or a diagnostic agent, and a medicament containing them are described, as are the pharmaceutically tolerated salts thereof. A process for their preparation, and their use as medicines and diagnostic aids in cardiovascular diseases, is also described.

Substituted bicyclic heteroaroylguanidines, a process for their

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Frankfurt-am-Main, Germany

Jan-Robert Schwark