The South African Nuclear Energy Corporation Limited

University of Cape Town

Northwest University

The South African Nuclear Energy Corporation (soc) Ltd.

Technische Universiteit Delft

Jan Rijn Zeevaart

Anne Frederica Grobler

Roger Hunter

Mohamed Iqbal Parker

Cathryn Helena Stanford Driver

David Randall Jansen

Geert Cornelis Krijger

Zvonimir Ivica Kolar

Johannes Samuel Frederik Botha

A method of obtaining, from a target compound, a radioisotope of a target element comprised in the target compound includes irradiating the target compound with high energy photon irradiation (gamma irradiation). Thereby the target element radioisotope is formed. The method is performed such that the target element radioisotope is of different oxidation state than the target element, and is comprised in a target element radioisotope compound that is separable from the target compound by a physical and/or chemical separation method.

Production of radioisotopes

This invention relates new radiopharmaceutical conjugates for use in improved methods of diagnosis and treatment of cancer. The radiopharmaceutical conjugate comprises, in sequence: a metabolite that targets tumour cells, bound to a chelating agent capable of containing a radionuclide, bound to a linker capable of binding with an EPR agent in vitro or in vivo; or a chelating agent capable of containing a radionuclide, bound to a metabolite that targets tumour cells, bound to a linker capable of binding with an EPR agent in vitro or in vivo. The radiopharmaceutical conjugates of the present invention provide active and passive targeted radio nuclide delivery systems that can help to improve the biodistribution and pharmacological toxicity of the radiopharmaceuticals used for the diagnosis and therapy of cancer.

Radiopharmaceutical conjugate of a metabolite and an EPR agent, for targeting tumour cells

This invention relates to a pharmaceutical composition for parenteral or oral administration containing a radioactive compound which can be used diagnostically or therapeutically. The composition comprises a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous or other pharmacologically acceptable carrier in which nitrous oxide is dissolved, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids, and the radioactive compound.

Pharmaceutical composition

The invention relates to a method of producing radionuclides. According to the method, a target medium comprising at least a target nuclide material is irradiated in an irradiation zone with neutron irradiation. Radionuclides form in the target nuclide material as a result of the irradiation, and at least some of the formed radionuclides are ejected from the target nuclide material. The ejected radionuclides are then captured and collected in a carbon-based recoil capture material which does not have an empty cage structure at crystallographic level.

Method of producing radionuclides

Growing community of inventors

Flaurana, South Africa

Jan Rijn Zeevaart