Ceskoslovenska Akademie Ved

Akademie Der Wissenschaften Der Ddr

Veb Leipziger Arzneimittel Werk

Ceskoslovenska Akademie Ved of Prague

Ceskoslovenska Akademie Ved of Praha

Jan Peska

Jiri Stamberg

Milan Benes

Dieter Bertram

Horst Dautzenberg

Herbert Lettau

Fritz Loth

Jiri Coupek

Frantisek Svec

Bodo Borrmeister

Frith Loth

Zdenko Blace

Zedenek Plichta

Jiri Lenfeld

The invention pertains to a method for the production of bead dextran materials for gel chromatography. The subject of the invention is a method for the production of bead dextran materials for gel chromatography, wherein dextran is, before or during the suspension process or in both stages, subjected to reduction in an alkaline solution, advantageously by the action of sodium borohydride, whereas the density of crosslinking is controlled above all by variation of the concentration of the initial dextran solution and the resulting gel may be optionally subjected to the additional crosslinking in a separate subsequent operation. The procedure according to the invention provides the product of higher quality with a lower content of carboxylic groups and substantially facilitates the preparation of gels with a very high and a very low crosslink density.

Method for the production of bead dextran materials for gel

An absorbing dressing for wounds consists of spherical particles of regenerated cellulose of the size 0.05-0.5 mm and a macroporous structure characterized by the cyclohexane regain of the dry material at least 0.2 ml/g. The dressing is prepared from the regenerated cellulose swollen with water by replacement with organic solvents and the subsequent drying of the product swollen with the said solvent and impregnated with a therapeutically active compound.

Dressing for wounds and the method for manufacturing thereof

A process of making a wound dressing is suggested, in which a technical conventional viscose solution is mixed with a polysaccharide derivative; the mixture is treated at increased temperatures such that it is thermally coagulated; the coagulate is wetted with a polyalkylene glycol and dried, whereby a particulate structure of the wound dressing is produced.

Method of producing absorbing wound dressing

The invention pertains to the absorbing dressing for wounds, which consists of spherical particles of regenerated cellulose of the size 0.05-0.5 mm (preferably 0.05-0.3 mm) and a macroporous structure characterized by the cyclohexane regain of the dry material at least 0.2 ml/g. The dressing is prepared from the regenerated cellulose swollen with water by replacement with organic solvents and the subsequent drying of the product swollen with the said solvent. The porous structure of the dressing warrants that it can absorb excretions of the wound in the amount 1.5 to 5 g water per g of solids; the grainy macrostructure remains preserved during the absorption so that the material applied on the wound in the form of a powder in the layer 2-5 mm thick, in particular 2-3 mm thick, can be without difficulties and almost without pain rinsed away with water.

Absorbing cover for wounds and the method for manufacturing thereof

The invention relates to quaternary cationic monomers and polymers and copolymers prepared thereof, based upon salts of methacrylic or acrylic esters of the general formula I ##STR1## where R.sup.1 is H or CH.sub.3

Quaternary salts of methacrylic or acrylic esters and cationic

Quaternary salts of methacrylic or acrylic esters

The invention relates to a method for manufacturing of spherical cellulose particles in bead form which enables to control the partial shape and porosity of the particles. Resulting cellulose sorbents are suitable carriers and materials for chromatography. The invented methods consists in heating a viscose (an aqueous solution of sodium cellulose xanthate) suspension in a water-immiscible liquid to 30.degree.-100.degree. C under stirring to form spherical droplets and solidify them and in the subsequent acidic decomposition of the solid xanthate globules either directly by addition of an acid soluble in the dispersion medium, or additionally after isolation and eventual washing of the particles to achieve the required wet volume. Liquids with the viscosity up to 100 cSt are advantageously used as dispersion medium and surfactants and/or modifying reagents (e.g. epichlorohydrine) may be added to the suspension.

Method for manufacturing of spherical cellulose particles

Quaternary salts of methacrylic or acrylic esters and cationic quaternay

The invention relates to chemically reactive polymers and copolymers of hydroxyalkyl methacrylate sulfo esters with monomer units of the formula ##EQU1## where n is an integer equal to 1 or 2 and R is C.sub.6 H.sub.5 --, p--CH.sub.3 C.sub.6 H.sub.4 --, or CH.sub.3 -- and to the method of manufacturing the technically useful articles from these polymers, namely crosslinked beads, membranes, blocks, etc., by free-radical polymerization or copolymerization in bulk, solution or in two-phase aqueous dispersion system under conditions whereby the hydrolysis of the sulfo ester is suppressed.

Polymers and copolymers of hydroxyalkyl methacrylate sulfo esters and

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Prague, Czechia

Jan Peska