Acadia Pharmaceuticals Inc.

Jan Pawlas

Nathalie Schlienger

Alma Fejzic

Carl-Magnus A Andersson

Roger Olsson

Eva Louise Hansen

Mikkel Boas Thygesen

Birgitte Winther Lund

Fabrizio Badalassi

Rasmus Lewinsky

Disclosed herein is a novel class of aminophenyl compounds having the structure: wherein Ris cyano or nitro and ring A is a bi- or tricyclic bridged heterocycle and to their use as modulators of androgen receptor for the treatment or prevention of conditions relating thereto.

Aminophenyl derivatives as selective androgen receptor modulators

Disclosed herein are compounds of Formula I, or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof. Also disclosed are methods of inhibiting an activity of a monoamine receptor comprising contacting the monoamine receptor or a system containing the monoamine receptor with an effective amount of one or more of the compounds of Formula I. Disclosed are also methods of inhibiting an activation of a monoamine receptor comprising contacting the monoamine receptor or a system containing the monoamine receptor with an effective amount of one or more of the compounds of Formula I. Furthermore, methods of treating psychotic disease using a compound of Formula I are disclosed.

N-substituted piperidine derivatives as serotonin receptor agents

Disclosed herein are bicycloaryl compounds of Formula (I) that selectively modulate nuclear receptors, preferably the androgen receptor, or a pharmaceutically acceptable salt, ester, amide, or prodrug thereof, and methods of treating disease comprising administering a compound of Formula (I) to a patient in need thereof.

Androgen receptor modulators and method of treating disease using the same

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Frederiksberg, Denmark

Jan Pawlas