Kingdom of the Netherlands

Jan Paul Van De Velde

Sebastianus J Halkes

Wolfgang Reischl

Silvia Kanzler

The invention relates to vitamin D analogs of general formula (I) wherein: R,is a hydrogen atom or a substituent selected from the group consisting of hydroxy, CH,OH, CH,CH,OH, CH,CH,CH,OH, OCH,, OCH,OH, OCH,CH,OH and OCH,CH,CH,OH; R,is a hydrogen atom or a substituent selected from the group consisting of OCH,, OCH,OH, CH,(CH,OH),(CH,CH,OH),, (CH,),OH and O(CH,),OH; wherein: m is 0 or 1, p, q and n are 0-3, r is 1-3 and m&plus;n&plus;p&equals;3; with the proviso that R,and/or R,contain at least one OH group; R,is a straight or branched, saturated or unsaturated aliphatic hydrocarbon of 6-13 C atoms which may be substituted with one or more substituents from the group hydroxy or fluoro. The invention further relates to methods of preparing these compounds, a pharmaceutical composition containing these compounds and to their use in pharmacotherapy and cosmetics.

Growing community of inventors

Weesp, Netherlands

Jan Paul Van De Velde