Nycomed Imaging As

Amersham Health As

Jan Olof Gustav Karlsson

Robertson Towart

Per Jynge

Bo Zieden

Hakan Malmgren

Helge Refsum

Derek Grant

Rolf Goran Gustav Andersson

Anders Olsson

Lars Goran Wistrand

Tudor Griffith

Chelating agents, in particular dipyridoxyl and aminopolycarboxylic acid based chelating agents, and their metal chelates, when linked directly or indirectly to at least one nitric oxide releasing moiety, or when use in combination with nitric oxide or a nitric oxide releasing moiety have been found to be effective in treating a variety of disorders. In particular, such compounds may be used in treating conditions associated with the presence of free radicals in the body, e.g. reperfusion injuries, and in reducing the cardiotoxicity of anti-tumor agents, e.g. anthracyclines and/or paclitaxel.

Nitric oxide releasing chelating agents and their therapeutic use

The invention provides the use of dipyridoxyl or aminopolycarboxylic acid based chelating agents, metal chelates and salts thereof, in the manufacture of a therapeutic agent for use in the treatment or prophylaxis of atherosclerosis and related conditions in the human or non-human animal body. Preferred compounds for use in the method of the invention are compounds of formula (I) or a metal chelate or salt thereof (wherein in formula (I) each R,independently represents hydrogen or &mdash;CH,COR,; R,represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamido; each R,independently represents a group XYR,; X represents a bond, or a C,alkylene or oxoalkylene group optionally substituted by a group R,; Y represents a bond, an oxygen atom or a group NR,; R,is a hydrogen atom, a group COOR,, an alkyl, alkenyl, cycloalkyl, aryl or aralkyl group optionally substituted by one or more groups selected from COOR,, CONR,, NR,, OR,, &boxH;R,, &boxH;O, OP(O)(OR,)R,and OSO,M; R,is hydroxy, an optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group; R,is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group; M is a hydrogen atom or one equivalent of a physiologically tolerable cation, e.g. an alkali or alkaline earth cation, an ammonium ion or an organic amine cation, such as a meglumine ion; R,represents a C,alkylene group, preferably a C,, e.g. a C,alkylene group, a 1,2-cycloalkylene group, or a 1,2-arylene group; each R,independently represents hydrogen or C,alkyl; and each R,independently may be absent or represents hydrogen, alkyl, hydroxyalkyl or carboxyalkyl).

Use of chelating agents in the treatment of atherosclerotic conditions

Growing community of inventors

Nesoddtangen, Norway

Jan Olof Gustav Karlsson