Bioarctic Neuroscience Ab

Other

Jan Näslund

Lars Lannfelt

Camilla Nilsberth

Anita Campbell

Anita Westlind-Danielsson

The invention relates to a purified antibody or fragment thereof that specifically binds an A&#x3b2; protofibril. The invention further relates to a composition that includes such antibodies. The invention also relates to using such antibodies and compositions for treating a patient having of suspected of having Alzheimer's disease.

Antibodies specific for amyloid beta protofibril

The present invention relates to prevention and treatment of Alzheimer's disease (AD). More specifically, the invention relates to use of a non-wild type protofibril or compound(s) with protofibril forming activity for active immunisation in the purpose of treating or preventing AD. The invention further relates to a peptide, A&#x3b2;-Arc, with high protofibril forming activity as well as several applications thereof, such as antibodies against said peptide for passive immunisation against AD.

Arctic &#x3b2; amyloid protofibril

A method for the treatment of Alzheimer's disease in a subject having or suspected of having Alzheimer's disease by administering to the subject a therapeutically effective amount of an antibody wherein the antibody is raised against a protofibril that contains an A&#x3b2;-Arc peptide.

Growing community of inventors

Stockholm, Sweden

Jan Näslund