Inion Ltd.

Isotis N.v.

C.c.a. Biochem B.v.

Jan Nieuwenhuis

Auvo Kaikkonen

Timo Pohjonen

Harri Happonen

Jeroen Mattijs Bezemer

Joost Robert De Wijn

Pia Ahvenjärvi

Eija Pirhonen

Pertti Helevirta

Franz Weber

Olli Karhi

Hermann Sailer

Piet E Haers

Arie Cornelis Mol

Timo Reunämaki

Timo Reunamäki

Jukka Koljonen

Tuomo Nieminen

A surgical implant made of a polymer, copolymer, polymer mixture or polymer composite that dissolves in the organ system. The manufacturing material is dyed with the coloring agent D&C Violet No. 2 or D&C Green No. 6. Preferably, the amount of the coloring agent is at most approximately 0.03 percent by weight and the implant is sterilized by radiation.

Surgical implant

A fastener for the treatment of fractures and the materials for production thereof. The fastener having a head with a contact portion for an installation tool and an attaching part having a treaded portion. The threads of the threaded portion are 5 to 20 % of the height of the outer diameter of the thread. The material for producing the fastener is a blend containing a biodegradable base material and one or more copolymer additives so that at room temperature the ductility of the blend is substantially higher than that of the pure base material. The base material may be a biodegradable polymer and/or a copolymer.

Bone fracture fastener and material for production thereof

An instrument for shaping a mouth part of a drilled tunnel provided in a bone. The instrument includes a shaft having a longitudinal axis and a first and a second end. The first end of the shaft is provided with a projection, which includes a blade for shaping the mouth part of the drilled tunnel when the instrument is turned around the longitudinal axis of the shaft. The instrument is asymmetric at an intersecting surface perpendicular to the longitudinal axis and intersecting with the blade, the instrument thus shaping the surfaces surrounding the first end only substantially within an area corresponding with a turning angle of such a turning movement.

Instrument

Novel polymer compositions that are useful in the manufacture of medical implants, implants having osteogenic properties and methods of making said implants are disclosed. Polymer compositions comprise a base material including a polymer matrix of resorbable polymer(s) or copolymer(s), and N-methyl-2-pyrrolidone (NMP), wherein NMP is present in an amount imparting osteogenic properties for the composition.

Resorbable polymer composition, implant and method of making implant

The invention relates to a process for molding a copolymer of a polyalkylene glycol terephthalate and an aromatic ester, comprising the steps of: a) preparing a solution of the copolymer in a suitable first solvent; and b) forming a gel of the solution.

Molding of a polymer

A novel polymer composition is provided which includes a base material including a biodegradable polymer or copolymer, and a copolymer additive including one or more monomers imparting a tensile strength to the polymer composition at room temperature that is lower than a tensile strength at room temperature for the base material.

Resorbable polymer compositions

The invention relates to a suture comprising a copolymer of a polyethylene glycol terephtalate and a polybutylene terephtalate, which copolymer comprises 45-60 wt. %, based on the weight of the copolymer, of the polyethylene glycol terephtalate, and 55-40 wt. %, based on the weight of the copolymer, of the polybutylene terephtalate.

Sutures

A polymer lactide is prepared by the polymerization of meso-3,6-dimethyl-1,4-dioxane-2,5-dione or mesodilactide and, if desired, other monomers. The mesolactide monomer has preferably a free acid content of less than 1 meq/kg dilactide and is then polymerized in a manner known per se. The compositions containing polymesolactide obtained according to this process do not posess the typical characteristics of poly-DL-lactide, poly-D-lactide or poly-L-lactide. A shorter degradation time of a substrate based on the present polymer is unofficial for several purposes. The present polymers have a good biocompatibility and are thus suited for bone plates, clamps and sutures and controlled release of biologically active compounds. The present polylactides and/or copolymers thereof have the benefit of a good biodegradability, biocompatibility, non-toxicity and non-mutagenicity.

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Gorinchem, Netherlands

Jan Nieuwenhuis