Institute of Organic Chemistry and Biochemistry of the Academy of

Rega Stichting, V.z.w.

K.u. Leuven Research & Development

Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic

Jan Marie Balzarini

Antonin Holy

Erik D De Clercq

Hana Dvorakova

Jindrich Jindrich

Erik Desire DeClercq

Erik Desire De Clercq

Dana Hockova

Resolved enantiomers of the formula ##STR1## wherein B is a purine or pyrimidine base or aza and/or deaza analogs thereof are useful in antiviral pharmaceutical compositions to treat retroviral infections.

Antiretroviral enantiomeric nucleotide analogs

N-(3-Fluoro-2-phosphonylmethoxypropyl) derivatives of purine and pyrimidine heterocyclic bases, method of producing them and their use as active principles of drugs. The invention relates to suppression of multiplication of viruses, particularly retroviruses, by application of the new compounds, N-(3-fluoro-2-phosphonylmethoxypropyl) derivatives of purine and pyrimidine heterocyclic bases. These compounds are obtained by the reaction of the N-(3-fluoro-2-hydroxypropyl) derivatives of purine and pyrimidine heterocyclic bases with diesters of p-toluenesulfonyloxymethylphosphonic acid in the presence of sodium hydride.

N-(3-fluoro-2-phosphonylmethoxypropyl) derivatives of purine and

Growing community of inventors

Heverlee, Belgium

Jan Marie Balzarini