Igen International, Inc.

Jan M Casadei

John H Kenten

Reid W Von Borstel

Mark T Martin

Richard J Massey

Rodger G Smith

Richard C Titmas

David M Simpson

Balreddy Kamireddy

Richard O Williams

Andrew D Napper

Michael Joseph Powell

Catalytic antibodies are disclosed. The catalytic antibodies are specific for prodrug compounds. The catalytic antibodies enhance cleavage of an active drug moiety from a prodrug residue, thereby activating the drug.

Prodrugs activated by targeted catalytic proteins

Prodrugs that are activated by and conjugated to a catalytic antibody conjugated to a moiety that binds to a tumor cell population are provided.

The invention relates to luminescent chimeric proteins which include a photoprotein and a second protein which may be light- or heavy-chain immunoglobulin, an antigenic peptide, avidin, streptavidin, or protein A. The invention also relates to chimeric protein genes, plasmids containing said gene, and hosts transformed with said plasmid. The invention also relates to a range of highly sensitive immunoassays which use the chimeric proteins.

Luminescent chimeric proteins

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Bethesda, MD, United States of America

Jan M Casadei