Ustav Organicke Chemie a Biochemie Av Cr, V.v.i.

Ustav Makromolekularni Chemie Av Cr, V.v.i.

Ustav Organicke Chemie a Biochemie Akademie Ved Cr, V.v.i.

Vysoka Skola Chemicko-technologicka V Praze

Univerzita Karlova V Praze, Prirodovedecka Fakulta

Univerzita Karlova

Ustav Anorganicke Chemie Av Cz

Department of Virology, University of Heidelberg

Ustav Organicke Chemie a Biochemie Av Cz

Ustav Organicke Chemie a Biochemie Akademie Ved Ceske Republiky, V.v.i.

Jan Konvalinka

Pavel Sacha

Jiri Schimer

Pavel Majer

Petr Cigler

Karel Ulbrich

Jiri Strohalm

Vladimir Subr

Tomas Knedlik

Vaclav Navratil

Vladimír Král

Martin Lepsík

Natan Sidej

Tereza Ormsby

Adela Simkova

Jochen Bodem

Hans-Georg Kräusslich

Jana Pokorná

Jaromír Plesek

Bohumír Grüner

Jana Prejdová

Milan Kozísek

Frantisek Sedlak

Jan Tykvart

Quinolinecarboxamide compounds of general formula I exceed the previously known FAP inhibitors in affinity and inhibitory effect. These agents can be used to specifically target tumours for diagnostic and therapeutic purposes, or for laboratory purposes in the study of endogenous FAP expression.

Compounds for inhibition of fibroblast activation protein

A method for detection of active form of analytes in a sample and/or for determination of ability of tested substances to bind to the active site of these analytes has the following steps: a) analyte or group of analytes from the sample is immobilized on the surface of a solid carrier; b) analyte or group of analytes is incubated with a detection probe; c) then the solid carrier is washed to remove unbound detection probe; and subsequently, the amount of bound detection probe is determined.

Method of detection of analyte active forms and determination of the ability of substances to bind into analyte active sites

A macromolecular water-soluble conjugates based on synthetic copolymers to which at least one affinity tag, at least one imaging probe and at least one targeting ligand are bound via covalent bonds. The macromolecular conjugate may be used in identification, visualization, quantification or isolation of proteins and/or cells.

Macromolecular conjugates for visualization and separation of proteins and cells

Synthetic macromolecular conjugate for selective interaction with proteins has a synthetic copolymer, and at least one binding group and at least one further group selected from an affinity tag and an imaging probe, and at least one binding group and at least one further group being bound via covalent bond to the synthetic copolymer. The macromolecular conjugate is suitable in particular for identification, visualization, quantification or isolation of proteins and/or cells.

Macromolecular conjugates for isolation, immobilization and visualization of proteins

The present invention provides novel HIV protease inhibitors containing substituted borane, carborane or metallacarborane clusters with 6 to 12 boron atoms in each cluster. The charge of each borane, carborane or metallacarborane cluster is 0, &#x2212;1 or &#x2212;2. The number of borane, carborane or metallacarborane clusters in the inhibitor molecule is 1 to 9, and the carborane clusters in metallacarborane inhibitors are coordinated to transition metal atom, selected from the group containing cobalt, iron, nickel and ruthenium. In the cluster, heteroatoms can be present, such as nitrogen, phosphorus, silicon, germanium, tin and sulphur. The present invention covers pharmaceutical compositions containing these inhibitors and their use, both in vitro and in vivo. They are characterized by high effectiveness and stability.

Chemical composition with borane clusters for use as an HIV protease inhibitor

Growing community of inventors

Prague, Czechia

Jan Konvalinka