Other

Washington University

Siga Pharmaceuticals, Inc.

Arexis Ab

Jan Kihlberg

Scott J Hultgren

Matti Juhani Lepisto

Charles Hal Jones

Zheng Xu

Meta Kuehn

Derek Ogg

Mark Harris

Rikard Holmdahl

Balik Dzhambazov

Jan Ake Engstrom

Harald Burkhardt

The invention relates a compound comprising (a) a peptide and (b) a carrier, wherein said peptide having at least the motif X-X-X-X-X-X-X, wherein at least one amino acid residue X is glycosylated, said peptide being linked to the peptide binding protein and said carrier comprises at least a MHC binding motif being linked to said peptide as well as pharmaceutical compositions comprising said compound and the use of said compound or pharmaceutical composition for the treatment of a disease, such as an inflammatory joint disease. The subject matter of the application is exemplified with peptides derived from type II collagen such as peptides having at least the sequence AGFKGEA, or IAGFKGEQPKG, or the peptide AAAKAAA. Preferably a hydroxylysine in the peptides are glycosylated.

Compound comprising an autoantigenic peptide and a carrier with a MHC binding motif

The invention provides methods and materials related to treating and diagnosing autoimmune conditions. Specifically, the invention provides polypeptide compositions, nucleic acids, substantially pure polypeptides, host cells, and methods for identifying a mammal with an autoimmune condition, treating a mammal with an autoimmune condition, and enhancing tolerance in a mammal with an autoimmune condition.

Triple polypeptide complexes

Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and thereby the infectivity of the bacteria is diminished. Also disclosed are methods for screening for drugs as well as methods for the de novo design of such drugs, methods which rely on novel computer drug modelling methods involving an approximative calculation of binding free energy between macromolecules. Finally, novel pyranosides which are believed to be capable of interacting with periplasmic molecular chaperones are also disclosed.

Treatment or prophylaxis of diseases caused by pilus-forming bacteria

Treatment of prophylaxis of diseases caused by pilus-forming bacteria

Compounds and pharmaceutical compositions for the treatment and prophylaxis of bacterial infections

Growing community of inventors

Dalby, Sweden

Jan Kihlberg