Ustav Experimentalni Botaniky Akademie Ved Ceske Republiky

Jan Holub

Miroslav Strnad

Karel Dolezal

Marek Zatloukal

Igor Popa

René Lenobel

Stefaan Werbrouck

Frank J Massino

Novel heterocyclic derivatives based on N-substituted adenine, having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.

[object Object]

Heterocyclic derivatives based on N-substituted adenine of, e.g.,a formula: wherein R2 is hydrogen, R6 is R6'-X, X is &#x2014;NH&#x2014;, and R6&#x2032; is substituted phenyl or substituted benzyl. The derivatives possess anticancer, mitotic, imunosuppressive and antisenescent properties for plant, animal and human cells, and methods of their preparation are disclosed. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.

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Olomouc, Czechia

Jan Holub