Ustav Organicke Chemie a Biochemie Av Cr, V.v.i.

Masarykova Univerzita

Ustav Makromolekularni Chemie Av Cr, V.v.i.

Fakultni Nemocnice U Sv. Anny V Brne

Jan Havlik

Petr Cigler

Pavel Krejci

Lukas Balek

Silvie Trantirkova

Lukas Trantirek

Jan Kucka

Martin Hruby

The present invention relates to a process for ion irradiation of a particulate substrate containing the steps of embedding particulate substrate in a solid matrix having 10B atoms, and exposing the matrix obtained in the previous step to a neutron flux to give irradiated particulate substrate. The process is extremely effective and amenable to large scale and is particularly suitable for producing irradiated nanodiamonds and irradiated SiC particles.

Method of production of irradiated particles

Nanodiamonds having a positive &#x3b6;-potential of at least 1 mV for use in sequestration of at least one FGF family member in organisms in vivo and in vitro. It has been found that nanodiamonds with a positive &#x3b6;-potential show an extremely strong and selective binding to FGF family members, thus leading to their usability in the treatment of diseases related to aberrant FGF-FGFR signalling and/or interaction.

Nanodiamonds as artificial proteins for regulation of a cell signalling system

Growing community of inventors

Znojmo, Czechia

Jan Havlik