Memorial Sloan Kettering Cancer Center

University of Central Florida Research Foundation Inc

Sanford Burnham Prebys Medical Discovery Institute at Lake Nona

Jan Grimm

Richard N Kolesnick

Steven M Larson

Charalambos Kaittanis

Santimukul Santra

Annette Khaled

Hampton Sessions

Oscar Santiesteban

Jesus Manuel Perez Figueroa

Matthew Dale Wall

Moritz F Kircher

Stefan Harmsen

Travis Shaffer

Tuula Penate-Medina

Oula Penate-Medina

Daniel L J Thorek

Provided herein is a nanoparticle for drug delivery, wherein the nanoparticle comprises a hyperbranched polyester (HBPE) nanoparticle having a hydrophobic interior, polyglutamate folate ligands conjugated to the nanoparticle, and one or more PET detectable isotopes. Also provided herein are methods of using thereof.

Methods and compositions for theranostic nanoparticles

Disclosed are compositions and methods for identifying a solid tumor cell target. Compositions and methods for treating prostate cancer are also disclosed. Further, cancer therapeutic compositions comprising CT20p are disclosed. Nanoparticles that are conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein are disclosed.

The present disclosure, among other things, provides new technologies for preparation of medical isotope labeled metal(loid) chalcogen nanoparticles for use in medical imaging and/or therapeutic applications. Provided technologies show a number of advantages as compared with previously available options for preparing and utilizing medical isotopes, including, for example, they utilize metal(loid) chalcogen nanoparticles that serve as universal binders (e.g., via covalent or non-covalent (e.g., chelate) bonds) for medical isotopes to provide medical isotope labeled metal(loid) chalcogen nanoparticles. Surprisingly, the same metal(loid) chalcogen nanoparticles may be used to bind (e.g., covalent or non-covalent e.g., chelation) bonding) a wide variety of different useful medical isotopes without the use of traditional chelating agents.

Metal(loid) chalcogen nanoparticles as universal binders for medical isotopes

Growing community of inventors

Larchmont, NY, United States of America

Jan Grimm