North Carolina State University

Becton Dickinson and Company Limited

Jan Genzer

Kirill Efimenko

Michael David Dickey

Andrea Liebmann-Vinson

Bryce Chaney

Pandiyarajan Chinnayan Kannan

Systems and methods relate to applying a coating to a substrate. Coatings can be generated using layer-by-layer application techniques. Typically, application of a first aqueous solution is alternated with application of a second aqueous solution. Example first aqueous solutions include polyethyleneimine (PEI) and hydroxy-terminated poly(dimethylsiloxane) (PDMS-OH). Example second aqueous solutions include silicate and PDMS-OH. In some instances, first aqueous solutions and/or second aqueous solutions additionally include methyl-terminated PDMS (PDMS-CH).

Substrate coatings: systems, methods, and techniques

The present invention provides methods of producing a surface with enhanced cell-adhesive properties comprising applying a stress to a polymeric matrix. The strained matrix is then modified by grafting a self-assembled monolayer onto the strained matrix, with the self-assembled monolayer comprising at least one exposed functional group. At least one cell-adhesive molecule can then be coupled to the at least one exposed functional group on the self-assembled monolayer to produce a surface with enhanced cell-adhesive properties.

Methods of surface modification of a flexible substrate to enhance cell adhesion

A method for forming a chemically patterned surface includes subjecting a surface of a substrate to a fluid including a component such that the component reacts with the surface to form a first distribution of the component on the surface. Thereafter, the surface is deformed along at least one axis such that the first distribution of the component is converted to a second distribution different from the first distribution. The second distribution is a gradient of the component.

Methods for forming tunable molecular gradients on substrates

Tailoring the grafting density of organic modifiers at solid/liquid interfaces

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Raleigh, NC, United States of America

Jan Genzer