Universiteit Twente

Cordis Europa N.v.

Cordis Corporation

Chienna B.v.

Dow Global Technolgoies LLC

University of Utah Research Foundation

Nederlandse Organisatie Voor Toegepast-natuurwetenschappelijk Onderzoek Tno

Akzo N.v.

Sentron V.o.f.

University of Twente

Academisch Ziekenhuis Bij De Universiteit Van Amsterdam

Ssens B.v.

Medisse B.v.

University of Twente, Institute for Biomedical and Technical Medicine (mira)

Hy2care B.v.

Jan Feijen

Pieter Jelle Dijkstra

Dirk Wybe Grijpma

Wilhelmus E Hennink

Zhiyuan Zhong

Jeroen Mattijs Bezemer

Gerardus H Engbers

Wilhelmus Everhardus Hennink

Clemens Antoni Van Blitterswijk

Rene Broos

Fenghua Meng

Donald E Gregonis

Hermanus Bernardus Johannes Karperien

Johannes C Rieke

Rong Wang

Robert V Peterson

Johannes G Terlingen

Jan Pleun Lens

Hilbert Esselbrugge

James M Anderson

Jan H Albers

Sunj-Wan Kim

Jan Olijslager

Marinus J Eenink

Pieter J Greidanus

Hendrik Roelof Stapert

Rong Jin

Liliana Sofia Moreira Teixeira

Erhan Bat

Niels Jurrian Sijbrandi

Ana Paula Gomes Moreira Pêgo

Jeroen Krijgsveld

Sebastianus Antonius Johannes Zaat

Jacob Dankert

Alma Johanna Kuijpers

Gerardus Henricus Maria Engbers

Pieter Jan Dijkstra

Gerardus Henricus Engbers

Jacob Hillebrand Goedemoed

Joost Dick De Bruijn

Christine Hiemstra

Ana Paula Gomes Moreira Pego

The invention relates to composition comprising a dextran-tyramine conjugate and a conjugate selected from the group consisting of chondroitin sulphate-tyramine, collagen-tyramine, chitosan-tyramine, chitosan-phloretic acid, gelatine-tyramine, heparan sulphate-tyramine, keratin sulphate-tyramine, hyaluronic acid-tyramine and heparin-tyramine.

Hydrogels based on polymers of dextran tyramine and tyramine conjugates of natural polymers

The present invention relates to a method for making a polymer wherein during ring opening polymerisation is incorporated into the polymer chain at least one cyclic (alkyl) carbonate monomer having the formula (1) wherein Y is optional and represents the residue of a sulfhydryl reacted group, X represents a functional group reactive with a sulfhydryl group, L=&#x2014;[CH2]n with n=0-10, or L=&#x2014;[CH2]p-S&#x2014;S&#x2014;[CH2]q with p and q are 0-5 or L=-[PEG]- with PEG is a group that comprises a &#x2014;[CH2CH2O]m-group with m=1-200, and R2 is hydrogen, methyl or ethyl. Optionally a cyclic (alkyl) acryloyl carbonate, or other additional monomer A may be used as comonomer. The polymer may be formed into a polymer article, such as a polymer film, such as a coating and modified and/or cross linked, to a polymer or polymer article obtainable, and to a biodevice, their use, and to the cyclic (alkyl)carbonates. 

Method for making a polymer, a polymer article, a biodevice, and cyclic carbonate

The present invention relates to methods for preparing a degradable polymer network. The methods for preparing a degradable polymer network comprise a) preparing a polymer composition comprising monomers of cyclic carbonates and/or cyclic esters and/or linear carbonates and/or linear esters and/or cyclic ethers and/or linear hydroxycarboxylic acids at a temperature between 20&#xb0; C. and 200&#xb0; C.; b) adding a cross-linking reagent comprising at least one double or triple C&#x2014;C bond and/or a cross-linking radical initiator; c) processing the polymer composition (that contains the crosslinking reagent into a desired shape; d) Crosslinking by irradiating the mixture. Further, the present invention relates to a degradable polymer network. Furthermore, the present invention relates to the use of the degradable polymer network.

Method for preparing a degradable polymer network

The present invention generally relates to a poly(bisoxalamide) and a process for preparing and article comprising the poly(bisoxalamide).

Poly(bisoxalamides)

The present invention relates to a process for the preparation of branched biodegradable polymers comprising of the steps of: (a) preparing a macromonomer by ring-opening polymerization of at least one cyclic ester, cyclic carbonate, and/or cyclic carboxyanhydride in the presence of a branching agent and optionally a catalyst; and (b) subsequent polycondensation of the macromonomer, to a process for the preparation of a macromonomer by ring-opening polymerization of at least one cyclic ester, carbonate and/or N-carboxyanhydride in the presence of a defined branching agent and optionally a catalyst, according to step (a), and to the prepared macromonomer and branched biodegradable polymer and their uses.

Branched biodegradable polymers, a macromonomer, processes for the preparation of same, and their use

The present invention relates to methods for providing shaped biodegradable and elastomeric structures of (co)polymers of 1,3trimethylene carbonate (TMC) with improved (mechanical) properties which can be used for tissue or tissue component support, generation or regeneration. Such shaped biodegradable elastomeric structures are obtainable by forming homopolymers and/or copolymers of 1,3-trimethylene carbonate (TMC) into a desired shape and irradiating said desired shape with actinic radiation in an inert atmosphere.

Method for providing shaped biodegradable and elastomeric structures of (co) polymers of 1,3-trimethylene carbonate (TMC), shaped biodegradable and elastomeric structures, and the use of these structures

The present invention relates to isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2 (TC-2), or variants thereof, which comprise at least in part the sequence as shown in FIG.indicated by the label TC-1 and TC-2, and have antimicrobial activity against gram-positive and gram-negative bacteria, for example, and, and/or against fungi, for example, andspec. The invention further relates to the use of said peptides, or variants thereof, for the preparation of a medicament for the treatment of bacterial or fungal infections, such as endocarditis, in humans and animals and the use of said peptides, or variants thereof, in release systems for prevention of bacterial or fungal infections in humans and animals.

Isolated and recombinant antimicrobial peptides thrombocidin-1 (TC-1) and thrombocidin-2(TC-2) or variants thereof

The invention relates to new biologically degradable aliphatic copolymers of the polyesteramide or polyesterurethane type. The invention further relates to a method for preparing the copolymers and to products which can be manufactured from the new copolymers.

Poly (ether ester amide) and poly (ether ester urethane) copolymers

A fibrous polymer implant loaded with one or more bioactive agents is prepared using a wet spinning technique. Preferably, an aqueous solution of bioactive agent is added to a solution of amphiphilic block copolymer containing hydrophilic blocks such as polyalkylene glycol and hydrophobic blocks such as an aromatic ester dissolved in a first solvent immiscible with water to form an emulsion. The emulsion is injected through a nozzle into a second solvent miscible with the first solvent in which the copolymer is essentially insoluble to form a solid copolymer fiber loaded with the bioactive agent. The fiber is shaped into an implant. Water content of the aqueous solution of bioactive agent affects rate of release of the bioactive agent in vivo. Bioactive agents include peptides, oligopeptides, polypeptides and proteins. The implant may be used as a carrier for controlled drug release or as a scaffold for tissue engineering.

Preparation of fibrous polymer implant containing bioactive agents using wet spinning technique

The invention provide biodegradable copolymers of the copoly(ester-amide) or copoly(ester-urethane) type, which copolymers consist of building blocks with the general structure (I): &lsqb;CB-VB&rsqb; wherein CB and VB of different building blocks may be the same or different, and CB represents a block with a constant length and VB represents a block with a variable length.

Copoly(ester-amides) and copoly(ester-urethanes)

The invention relates to a method for providing a surface with carboxyl groups. A compound is applied to the surface with at least one functional group which can be converted into a carboxyl group. Thereafter, this surface is treated with a plasma to immobilize the compound, and then the functional group is converted into a carboxyl group. Also provided is a surface having carboxyl groups which is obtained with this method and a product with such a surface for exposure to blood, typically in vivo blood flows.

Providing a surface with carboxyl groups and surface and product thus

Article for the controlled delivery of an active substance, comprising a

A dicarbonyl halide preferably a straight-chain-alkyl dicarbonyl dihalide, may be used to activate a substrate surface of preferably polyurethane or polyamide. Optionally, an amine-end blocked polymer may be reacted with the resulting activated surface by reaction between amine and dicarbonyl halide groups. Then, a material to be covalently bonded to said surface, such as heparin, may be reacted with free amine groups bonded to the surface by a carbodiimide process or the like.

Process for activating a polymer surface for covalent bonding for

A substrate for medical devices and a process for making the substrate is provided, the substrate having on at least part of its surface a blood-compatible surface produced by coupling a physiologically active substance to the surface. The physiologically active substance is one having an inhibitory effect on the formation of blood clots and/or is capable of breaking down blood clots formed. The physiologically active substance is bonded to a polyacid, and the polyacid is attached to the surface by a covalent bond.

Covalent attachment of anticoagulants and the like onto biomaterials

Biodegradable hollow fibres with an asymmetric wall, the cavity of which containing an active substance like a drug, hormone etc. or a dilute form of the latter and both ends of the hollow fibre being closed for the controlled release of the active substance as well as a process for the manufacturing of such hollow fibres.

Biodegradable polymer substrates loaded with active substance suitable

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Hengelo, Netherlands

Jan Feijen