Schering Corporation

Jan E De Vries

Benjamin G Cocks

Chia-Chun J Chang

Gregorio Aversa

Rene De Waal Malefyt

Kevin W Moore

Paul J Zavodny

Satwant K Narula

Jacques F Banchereau

Chung-Her Jenh

Paulo J Vieira

Maria-Grazia Roncarolo

Anne-Catherine Fluckiger

Rosa Bacchetta

Herve M Groux

Rene De Malefyt

Interleukin-10 for producing a population of cells which are capable of inhibiting or suppressing reactions to alloantigens, for example in graft-versus-host disease or tissue rejection, is described. Interleukin-10 for reducing responses in mixed lymphocyte response (MLR) is also described. Exogenous or induced endogenous IL-10 may be used for the inhibition or suppression of the reactions to alloantigens.

Methods for modulating antigen-specific immune responses

Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding this antigen. Methods of using said reagents and diagnostic kits are also provided.

Methods for modulating SLAM-expressing T cells

Purified genes encoding a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigen. Methods of using said reagents and diagnostic kits are also provided.

Purified genes encoding mammalian cell surface antigens; proteins and antibodies

A method is provided for treating tumors, e.g., lymphocytic leukemias, which comprises administering to a mammal an effective amount of interleukin-10.

Treatment of neoplastic disease with interleukin-10

Use of interleukin-10 to produce a population of suppressor cells

Stably-transformed human cell lines containing a reporter gene operatively linked to an IL-4-responsive element are provided. In some embodiments a human Fc,RII IL-4-responsive element is used. In other embodiments a human germline &egr; transcript promoter is used as the responsive element. Also provided are methods for using such transformed cell lines to screen for agonists and/or antagonists of human interleukin-4.

Materials and methods for screening human interleukin-4 antagonists/agonists

Mammalian cell surface antigens

Stably-transformed human cell lines containing a reporter gene operatively linked to an IL-4-responsive element are provided. In some embodiments a human Fc.sub..epsilon. RII IL-4-responsive element is used. In other embodiments a human germline .epsilon. transcript promoter is used as the responsive element. Also provided are methods for using such transformed cell lines to screen for agonists and/or antagonists of human interleukin-4.

Human interleukin-4 antagonist/agonist screens

Purified genes which encode a T cell surface antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigen. Methods of using said reagents and diagnostic kits are also provided.

Growing community of inventors

Los Altos, CA, United States of America

Jan E De Vries