Tron—translationale Onkologie an Der Universitatsmedizin Der Johannes Gutenberg-universitat Mainz Ggmbh

Biontech Se

Biontech Rna Pharmaceuticals Gmbh

Tron—translationale Onkologie an Der Universitátsmedizin Der Johannes Gutenberg—universität Mainz Gemeinnützige Gmbh

Tron - Translationale Onkologie an Der Universitatsmedizen Der Johannes Gutenberg-universitat Mainz Gemeinnutzige Gmbh

Jan Diekmann

Ugur Sahin

Michael Koslowski

Sebastian Kreiter

Mustafa Diken

Tana Omokoko

Christian Bender

Claudia Paret

Kirsten Vormbrock

Martin Löwer

John Christopher Castle

Bernhard Renard

Johannes Hendrikus De Graaf

Cedrik Britten

Martin Lower

The present invention relates to a patient-specific tumor treatment targeting individual expression patterns of tumor antigens, in particular shared tumor antigens, and individual tumor mutations. In one aspect, the present invention relates to a method for preventing or treating cancer in a patient comprising the steps of: (i) inducing a first immune response against one or more tumor antigens in the patient, and (ii) inducing a second immune response against one or more tumor antigens in the patient wherein the second immune response is specific for cancer specific somatic mutations present in cancer cells of the patient.

Individualized vaccines for cancer

The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases. In one aspect, the present invention relates to a method for providing an individualized cancer vaccine comprising the steps: (a) identifying cancer specific somatic mutations in a tumor specimen of a cancer patient to provide a cancer mutation signature of the patient; and (b) providing a vaccine featuring the cancer mutation signature obtained in step (a). In a further aspect, the present invention relates to vaccines which are obtainable by said method.

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Mainz, Germany

Jan Diekmann