Fujifilm Manufacturing Europe B.v.

Fuji Photo Film B.v.

Fuji Photo Manufacturing Europe B.v.

Jan Bastiaan Bouwstra

Yuzo Toda

Andries Johannes Jozef Van Es

Peter Franciscus Theresius Maria Van Asten

Arjo De Boer

Hendrik Van Urk

Eugen Aldea

Mauritius Cornelius Maria Van De Sanden

Sebastianus Gerardus Johannes Maria Kluijtmans

Marc Willem Theodoor Werten

Tanja Jacoba Van Den Bosch

George Valentino Van Heerde

Andreas Mooibroek

Hindrik De Vries

Serguei Alexandrovich Starostine

Frederik Anton De Wolf

Richèle Deodata Wind

Hendrik Wouter Wisselink

Joseph Hubertus Olijve

Hindrik Willem DeVries

Gertjan Bögels

Alexis Comelus Van Rijn

Wim Jiskoot

Wilhelmus Everhardus Hennink

Sebastianus Gerardus Kluijtmans

Marc Sutter

Raymond Lurvink

Paul Peeters

Hindrik Willem De Vries

Sebastianus Gerardus J M Kluijtmans

Huib Van Boxtel

Ieke De Vries

Marc Willem Werten

Alexis Cornelus Van Rijn

Hindrik Wilem DeVries

Rich&eacute;le Deodata Wind

Tanja Jacoba Bosch Van Den

Richéle Deodata Wind

Frederik Anton Wolf De

Yoichiro Kamiyama

Sebastianus Kluijtmans

Elisabeth Van Dongen

Sebastianus Gerardus Johannes Maria Kluijtmants

Arjo Lysander De Boer

Peter Franciscus Theresius Van Asten

The invention relates to collagenous polypeptide films on which cells are cultivated. In particular the invention relates to such films that are used to treat wounds such as severe burns or physical or chemical injury. The invention also related to methods for producing such films.

Non-porous film for culturing cells

The invention relates to the field of pharmacology. More specific, the invention relates to a controlled release composition. In one of the embodiments, the invention provides a method for preparing a controlled release composition comprising the steps of:

Controlled release composition comprising a recombinant gelatin

The invention concerns recombinant gelatin monomers and recombinant gelatins comprising or consisting of multimers of the monomers. The recombinant gelatins can be produced with enhanced stability.

Non-natural recombinant gelatins with enhanced functionality

The invention concerns recombinant gelatin monomers and recombinant gelatins comprising or consisting of multimers of the monomers. The recombinant gelatins are of particular use in several applications involving cell attachment such as in cell culture work and applications involving cell cultures of anchor dependent cells and also in a variety of medical applications.

Recombinant XRGD-enriched gelatins having high stability

The invention relates to new, highly efficient UV-absorbing compounds, a process for their manufacturing and to uses of these UV-absorbing compounds. The UV-absorbing compounds are in particular UV-A-absorbing compounds according to Formula (VI) or (VII):RCH&#x2014;N(R)&#x2014;(CR)&#x2014;N(R)&#x2014;CHR&#x2003;&#x2003;(VI)N{(R)[(CR)-N(R)&#x2014;CHR]n}&#x2003;&#x2003;(VII).

UV absorbing compounds

The invention concerns recombinant gelatins with unevenly distributed RGD motifs that are of particular use in several applications involving cell attachment such as in cell culture work and applications involving cell cultures of anchor dependent cells and also in a variety of medical applications.

RGD containing recombinant gelatin

A composition comprising a purified collagen-like polypeptide suitable as a peptizer, said polypeptide comprising [Gly-X-Y]n repeats, wherein Gly stands for glycine, X and Y represent any amino acid and n is an integer and selected such that the length of the [Gly-X-Y]n repeat is at least 2.5 kDa and wherein the amino acid sequence of said [Gly-X-Y]n repeats comprises more than 4 different amino acids and wherein said purified polypeptide is free of helix structure.

Method for recombinant microorganism expression and isolation of collagen-like polypeptides

The invention concerns a recombinant CBE gelatin and recombinant gelatins having multimers of the CBE monomer sequence that are of particular use in several applications involving cell attachment such as in cell culture work and applications involving cell cultures of anchor dependent cells and also in a variety of medical applications.

Recombinant gelatins

The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.

Use of RGD-enriched gelatine-like proteins for inhibition of cancer metastasis

The invention relates to the field of pharmacology. More specific, the invention relates to a controlled release composition. This invention is related to a controlled release composition comprising a cross-linked gelatin and at least one therapeutic protein wherein the ratio of the average mesh size (&#x3be;) of the gelatin matrix and the average hydrodynamic radius (R) of the therapeutic protein is smaller than 2, preferably smaller than 1.5.

Controlled release composition

A composition comprising a purified collagen-like polypeptide suitable as a peptizer, said polypeptide comprising [Gly-X-Y] repeats, wherein Gly stands for glycine, X and Y represent any amino acid and n is selected such that the length of the [Gly-X-Y] repeat is at least 2.5 kDa and wherein the amino acid sequence of said polypeptide comprises more than 4 different amino acids and wherein said purified polypeptide is free of helix structure.

Composition comprising a purified collagen-like polypeptide suitable as a peptizer

Method for prevention of platelet aggregation employing and RGD-enriched gelatine-like protein

The present invention relates to a method of and arrangement for removing contaminants from a surface of a substrate by subjecting said substrate surface to an atmospheric pressure glow plasma. Said plasma is generated in a discharge space comprising a plurality of electrodes, by applying an alternating plasma energizing voltage to said electrodes causing a plasma current and a displacement current. Said plasma is stabilised by controlling said displacement current during plasma generation such that modification of properties of said substrate surface is prevented.

Method of and arrangement for removing contaminants from a substrate surface using an atmospheric pressure glow plasma

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Bilthoven, Netherlands

Jan Bastiaan Bouwstra