Instytut Chemii Bioorganicznej Pan

Centre National De La Recherche Scientifique

Uniwersytet Medyczny Im. Karola Marcinkowskiego

Bioinfobank Sp. Z O. O.

Jan Barciszewski

Eliza Wyszko

Katarzyna Rolle

Marcin Krzysztof Chmielewski

Leszek Rychlewski

Wojciech T Markiewicz

Ewelina Adamska

Maria Markiewicz

Lech Celewicz

André Dietrich

Krzysztof Ciszewski

Monika Nowak

Stanisaw Nowak

Ryszard Zukiel

Iwona Gawronska

Miroslawa Barciszewska

Tadeusz Kulinski

Agnieszka Fedoruk-Wyszomirska

Malgorzata Giel-Pietraszuk

Beata Plitta

Theo Dreher

Clarisse Valentin

Romain Val

Andre Dietrich

The present invention relates to a polyribonucleotide including a hammerhead trans-ribozyme directed against a plant mitochondrial RNA and a structure in the form of tRNA that can be aminoacylated by valine, and to the use thereof in plants in particular for inducing cytoplasmic male sterility.

Importation of a ribozyme into vegetable mitochondria by a pseudo-tRNA that can be aminoacylated by valine

A cytosine analog, a method of preparation of a cytosine analog, a DNA methyltransferase 1 inhibitor, and a method for DNA methylation inhibition, is provided for the treatment of diseases associated with deviations from normal DNA methylation. The analog of cytosine may be comprised of 1, N, 5 and 6-substituted derivatives of cytosine or 5,6-dihydrocytosine, wherein the analog can be described by the chemical formula  where Ris H, R, R, 2'-deoxyribosyl, Ris alkyl or aryl, X is N or C, wherein if X in the analog of formula I is N, then Ris no substituent and if X in the analog of formula I and/or II is C or if X in the analog of formula II is N, then Rand Rare independently alkyl, aryl, hydroxyalkyl, aminoalkyl, hydroxyl, carboxyl, amino group, alkoxyl, aryloxyl, aminoalkyl, aminoaryl, thio group, sulfonyl, sulfinyl or halogen.

Cytosine analogue, a method of preparation of a cytosine analogue, a DNA methyltransferase 1 inhibitor, a method for DNA methylation inhibition, the use of the analogue in the treatment of diseases associated with deviations from normal DNA methylation

The subject matters of this invention are a sequence of double-stranded RNA: ATN-RNA, intervention using interference RNA (iRNAi), use of a sequence of double-stranded RNA: ATN-RNA, a method of treating a brain tumor and a method of inhibiting a brain tumor cells which express tenascin, a kit for inhibiting cancer cell which expresses tenascin and a method for a kit preparation in a brain tumor therapy. Malignant gliomas preferentially express a number of surface markers that may be exploited as therapeutic targets, including tenascin-C, an extracellular matrix glycoprotein that is ubiquitously expressed by malignant gliomas and probably contributes to tumor cell adhesion, invasion, migration and proliferation. For tenascin-C inhibition, RNA interference intervention (iRNAi) approach have been applied.

Sequence of dsRNA: ATN-RNA specific for tenascin-C

The subjects of the present invention are the method of preparation of 4-furfurylcytosine and/or its derivatives, its use in the manufacture of anti-aging compositions and an anti-aging composition. As 4-furfurylcytosine and/or its derivatives possesses a series of biological properties it might be use as a composition having excellent anti-aging effect to prevent the sagging of skin and loss of luster and to improve sufficiently its aesthetic appearance without significantly change the growth rate and the total growth ability of the skin. Optimal methods of manufacturing this compound, while at the same time obtaining the highest possible process efficiency, with particular emphasis on its utility in the pharmaceutical and cosmetic industries are presented.

Method of obtaining of 4-N-furfurylcytosine and/or its derivatives, an anti-aging composition and use of 4-N-furfurylcytosine and/or its derivatives in the manufacture of anti-aging composition

The subjects of the present invention are a method of manufacturing 3-(4-hydroxyphenyl)propanoic acid amide, its application in the manufacture of anti-aging compositions and an anti-aging composition. As phloretamide possesses a series of biological properties it might be use as a composition for skin having excellent anti-aging effect to prevent the sagging of skin and loss of luster.

Method of manufacturing 3-(4-hydroxyphenyl)propanoic acid amide, its application in the manufacture of anti-aging compositions and anti-aging composition

Growing community of inventors

Poznan, Poland

Jan Barciszewski