Institut National De La Sante Et De La Recherche Medicale

Université Paris—sud

Commissariat &#xc0; L'&#xc9;nergie Atomique Et Aux &#xc9;nergies Alternatives

Assistance Publique-hopitaux De Paris

Université Grenoble Alpes

Institut National De La Recherche Agronomique (inra)

Centre Hospitalier Universitaire

Alfact Innovation

Université Paris Descartes

Centre Hospitalier Universitaire Grenoble Alpes

Université De Paris Xi Paris Sud

Inserm

The Healthy Aging Company

Brechot, Christian

Jamila Faivre

Christian Bernard Brechot

Marion Darnaud

Joël Dore

Virginie Brun

Laure Jamot

Paul Amouyal

Gilles Amouyal

Jean-Pierre Zarski

Christophe Magnan

Jérôme Garin

Vincent Leroy

Eric Vibert

Christophe Bruley

Fabrizio Andreelli

Nicolas Moniaux

Pierre Gressens

Elodie Rougier

Céline Cruciani-Guglielmacci

Julie Herve

Jérôme Clerc

The invention concerns a Reg3&#x3b1; polypeptide (also known as Hepatocarcinoma-Intestine-Pancreas/Pancreatitis Associated Protein (HIP/PAP)) for use in the protection of oxygen sensitive gram-positive bacteria, compositions comprising the polypeptide and their use. The inventors have shown that an increase in the concentration of the h Reg3&#x3b1; lectin into the gastrointestinal tract (GIT) lumen of hReg3&#x3b1;-transgenic mice induced significant changes in the composition of the gut microbiota, and dramatically improved host resistance to intestinal inflammation. hReg3&#x3b1; exerted a potent antioxidant activity on intestinal epithelial cells during colitis, and in particular the ROS scavenging activity, in particular, by promoting the survival of highly oxygen sensitive bacteria. Inventors also showed that h Reg3&#x3b1;-transgenic mice resist better to DSS-induced colitis after antibiotherapy. Thus, the invention concerns a Reg3&#x3b1; polypeptide for use in the protection of oxygen sensitive gram-positive bacteria, notably the Ruminococcaceae, such as, and/or the Lachnospiraceae, such as; pharmaceutical compositions comprising the polypeptide and their use; and the use of this polypeptide for promoting ex vivo growth of oxygen sensitive gram-positive bacteria. The Reg3&#x3b1; polypeptide may be used for preventing or treating microbiota-related disease and/or disorder, particularly selected from inflammatory bowel disease (IBD), colitis, gastrointestinal infections, irritable bowel syndrome and other gastrointestinal functional diseases, gastrointestinal tract cancer, metabolic syndrome and obesity, diabetes, liver diseases, allergic diseases, neurodegenerative diseases and psychological disorders.

Polypeptide for use in the protection of oxygen sensitive gram-positive bacteria

Process for in vitro diagnosis and/or monitoring and/or prognosis and/or theranosis of hepatic disorders from a biological sample originating from a subject, in which process the presence and/or the concentration of the marker ADH1B (SEQ ID NO.2) and/or the presence and/or the concentration of the combination of the markers ADH1B (SEQ ID NO.2) and ADH1A (SEQ ID NO.1) is determined.

Process for in vitro diagnosis of hepatic disorders

This invention concerns a HIP/PAP protein or derivative thereof, for its use in treating or managing cancer and preferentially solid tumors.

HIP/PAP protein and derivatives thereof for use in treating cancer

Growing community of inventors

Paris, France

Jamila Faivre