The Brigham and Women's Hospital, Inc.

Exosome Diagnostics, Inc.

The General Hospital Corporation

Jamil Azzi

Johan Karl Olov Skog

Ralph Weissleder

Hakho Lee

Cesar Castro

Robert Kitchen

Hsing-Ying Lin

Vasisht Tadigotla

James Hurley

Christine Coticchia

Sangmoo Jeong

Jongmin Park

The invention relates generally to the use of microvesicle biomarkers such as nucleic acids, including nucleic acid signatures, and/or proteins for assessing a kidney transplant rejection in a patient. The invention further relates to assessing, and/or to monitoring kidney transplant rejection in patients who have received a renal transplant.

Methods of detecting renal transplant rejection using microvesicle nucleic acid biomarkers

The invention relates generally to the use of microvesicle RNA signatures for diagnosis, predicting, and/or to monitor treatment efficacy, including patients who are candidates for renal transplant and/or who have received a renal transplant.

Profiling microvesicle nucleic acids and uses thereof as signatures in diagnosis of renal transplant rejection

Target analyte detection devices include a housing having a potentiostat and a microcontroller coupled to the potentiostat. The device also includes a substrate having a plurality of electrodes on a first surface of the substrate. A first set of electrodes of the plurality of electrodes defines a first sample detection region. The substrate is removably attachable to the housing such that the first set of electrodes is coupled to the potentiostat upon attaching the substrate to the housing. The device also includes a magnet assembly couplable to a second surface of the substrate. The magnet assembly includes a magnet positioned in the magnet assembly such that a magnetic field from the magnet extends through the substrate and the first set of electrodes into an area above the first sample detection region upon coupling the magnet assembly to the substrate.

Magnetic electrochemical sensing

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Boston, MA, United States of America

Jamil Azzi