3m Innovative Properties Company

Alcon Laboratories, Inc.

Jamieson C Keister

Michael D Delmore

Richard H Ferber

Patrick R Fleming

Michael K Domroese

Daniel C Duan

Graham M Clarke

Cristina U Thomas

Cheryl L Moore

Franklyn L Frederickson

John C Lang

James E Garbe

Douglas A Huntley

Rachael A T Gould

Chan U Ko

Paul J Missel

Tai-Lee Ke

Rebecca L Everman

Douglas F Hager

Eugene R Cooper

Dimitri J Stancioff

Jay D Jacobs

Kathleen K Reynolds

Rachael At Gould

Microneedle devices with microneedles having a truncated tapered shape are disclosed. The microneedles of microneedle devices may also have a controlled aspect ratio. Microneedle delivery apparatus are disclosed that include drivers designed to deliver microneedles at velocities that may enhance perforation of the stratum corneum while limiting the sensation of pain experienced at the delivery site.

Microneedle devices and microneedle delivery apparatus

The present application is directed to a coating composition comprising a ceramic binder and inorganic copper compound particles. Generally, the inorganic copper compound particles have a median particle size of less than 5 micrometers. In some embodiments, the particles have a median particle size of greater than 1 micrometer. The inorganic copper compound particles may be non-photocatalytic. The coating may also be placed on a structural layer.

Copper containing algicidal compounds

A transdermal drug delivery device involving a macromonomer-containing acrylate or methacrylate copolymer, a softener, and a drug. Also a pressure sensitive skin adhesive involving a macromonomer containing acrylate or methacrylate copolymer and a softener.

Matrix for transdermal drug delivery

Microneedle arrays, methods of manufacturing microneedles and methods of using microneedle arrays. The microneedles in the microneedle arrays may be in the form of tapered structures that include at least one channel formed in the outside surface of each microneedle. The microneedles may have bases that are elongated in one direction. The channels in microneedles with elongated bases may extend from one of the ends of the elongated bases towards the tips of the microneedles. The channels formed along the sides of the microneedles may optionally be terminated short of the tips of the microneedles. The microneedle arrays may also include conduit structures formed on the surface of the substrate on which the microneedle array is located. The channels in the microneedles may be in fluid communication with the conduit structures. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue.

Microneedle arrays and methods of manufacturing the same

Topical ophthalmic compositions of carrageenans which are administrable as a drop but which become more viscous or gel upon instillation in the eye are disclosed. Methods for use of the compositions as topical ophthalmic vehicles for pharmaceutically active agents, and alone as lubricants or tear supplements, are also disclosed.

Use of carrageenans in topical ophthalmic compositions

The use of monoacyl phosphoglycerides to enhance the penetration of topically applied ophthalmic drugs through the corneal epithelium is described.

Use of monoacyl phosphoglycerides to enhance the corneal penetration of

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Lakeville, MN, United States of America

Jamieson C Keister