Bikam Pharmaceuticals Inc.

Jamie B Côté

David S Garvey

Jeremy Robert Greenwood

Gregory J LaRosa

Judd Berman

Tan Quach

Leah Lynn Frye

Mark L Brewer

Gregory Larosa

Compounds and compositions of said compounds along with methods of use of compounds are disclosed for treating ophthalmic conditions related to mislocalization of opsin proteins, the misfolding of mutant opsin proteins and the production of toxic visual cycle products that accumulate in the eye. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described.

Opsin-binding ligands, compositions and methods of use

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic is visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

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Newmarket, Canada

Jamie B Côté