Medimmune Limited

Humabs Biomed Sa

Medlmmune Limited

Jamese Johnson Hilliard

Charles K Stover

Davide Corti

Bret Sellman

Xiaodong Xiao

Martina Beltramello

Elisabetta Cameroni

Chew-shun Chang

Qun Wang

Gilad Kaplan

Meghan Pennini

Partha S Chowdhury

Melissa Marie Damschroder

Reena Varkey

Christine Tkaczyk

Lei Hua

Vaheh Oganesyan

Li Peng

Omari Jones

Bret R Sellman

Christine J Tkaczyk

Reena M Varkey

Charles Ken Stover

The present disclosure provides binding proteins (e.g., antibodies or antigen binding fragments thereof) that specifically bind toO1 and induce opsonophagocytic killing of(e.g.,). The present disclosure also provides methods of reducing(e.g.,) or treating or preventing(e.g.,) infection in a subject comprising administering theO1 binding proteins, (e.g., antibodies or antigen-binding fragments thereof) to the subject.

Anti-O1 antibodies and uses thereof

Provided herein are methods of preventing and treating polybacterial infections comprising administering an effective amount of an antibody or antigen-binding fragment thereof that specifically binds to an epitope produced by at least one of the bacterium in the polybacterial infection. For example, an antibody that specifically binds toalpha toxin can be administered to a patient with a polybacterial infection comprisingandto inhibit the growth of

Treatment of polybacterial infections

Herein provided are compositions, methods of manufacture and methods of use pertaining to anti-alpha toxin antibodies and fragments.

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Growing community of inventors

Gaithersburg, MD, United States of America

Jamese Johnson Hilliard