Afasci, Inc.

Advanced Micro Devices Corporation

Spansion Llc.

James Xie

Fei Wang

Steven C Avanzino

Sameer S Haddad

Jeffrey Allan Shields

Suzette Keefe Pangrle

Bryan K Choo

Manuj Rathor

Michael Vanbuskirk

Christie Marrian

Kevin Song

Xinmin Xie

Conrado Pascual

Xi Xie

The present invention provides compositions, and methods for local administration of certain peptides or combination with certain small molecules that produce analgesia and anti-inflammation in a mammal. Exemplary polypeptides provide peripheral analgesia and anti-inflammation when administered via local topical, subcutaneous, intradermal, or intranasal administration, to provide analgesia and anti-inflammation. Through antagonism of peripheral CGRP receptors alone, or in combination with inhibition of sensory sodium channels or anti-inflammation, the compositions of the invention provide local therapeutic pain relief with minimal undesired systemic side effects in a subject. Also provided are improved peptide delivery techniques including microneedle unit dose administering apparatus and methods. Also provided are hydrogel formulations for sustained local delivery to a subject of one or more of the compositions according to the invention in a therapeutically effective amount, thereby providing local pain relief and/or reducing associated inflammation.

Compositions and methods for treating acute and chronic pain by local antagonism of CGRP receptors, or combination with sodium channel inhibition or with anti-inflammatory agents

Growing community of inventors

Brookline, MA, United States of America

James Xie