Armour Pharmaceutical Company

James Winslow Bastian

John Lawrence Hughes

Robert Chung-Huan Liu

Takashi Enkoji

Francine B Caulin

A method of obtaining suppression of gastric acid secretion in a mammalian host by the oral administration of calcitonin to the host mammal, including man, to obtain the suppression of gastric acid secretion therein. The method is useful in the treatment of mammals having grastric or duodenal ulcers or other conditions which benefit from the suppression of gastric acidity.

Method of suppressing gastric acid secretion by the oral administration

Pharmaceutical preparations and methods of using the same to treat a host having a condition requiring vasoconstrictive therapy. The preparations comprise a pharmaceutically acceptable carrier and a guanidine compound, or non-toxic acid addition salt thereof, having the structural notation: ##SPC1## Wherein: R.sub.1 is hydrogen or alkyl having 1-4 carbon atoms; R.sub.2 is hydrogen, hydroxy, chloro, fluoro or bromo; and R.sub.3 is hydrogen or the same as R.sub.2 when R.sub.2 is chloro, bromo or fluoro.

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Park Forest, IL, United States of America

James Winslow Bastian