Abbott Laboratories Corporation

James Wieler

Larry L Green

Xiao-Chi Jia

Jaspal Singh Kang

Tariq Ghayur

Boris Labkovsky

John Stephen Babcook

Jeffrey W Voss

Brad Hedberg

Edward B Reilly

Peter J DeVries

David H Ostrow

The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

IL-18 binding proteins

The present invention relates to antibodies and antibody fragments thereof that bind to and activate an erythropoietin receptor. The present invention also relates to methods of modulating the endogenous activity of an erythropoietin receptor in a mammal using said antibodies as well as pharmaceutical compositions containing said antibodies.

Erythropoietin receptor binding antibodies

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Beverly, MA, United States of America

James Wieler