Vanderbilt University

Cumberland Pharmaceuticals, Inc.

Aggenetics, Inc.

Acceligen, Inc.

Cumberland Pharmaceuticls Inc.

James West

Leo Pavliv

L Jackson Roberts, Ii

Erica J Carrier

Bryan Voss

Ines Macias-Perez

Susan M Majka

Pavliv Leo

Joshua P Fessel

The present invention is directed to methods of treating, preventing, and/or ameliorating fibrosis syndrome, and in particular cardiac fibrosis, by administration of a therapeutically effective amount of ifetroban, or a pharmaceutically acceptable salt thereof.

Compositions and methods of treating cardiac fibrosis with ifetroban

The subject invention provides materials and methods for producing animals with short hair length. In a preferred embodiment, this is accomplished by altering in the animal the nucleotide sequence that encodes the prolactin receptor (PRLR) protein such that a truncated version of the protein is produced. Advantageously, and surprisingly, the truncated protein produced according to the subject invention retains lactogenic functionality, but causes the animal to have a short-hair coat.

Materials and methods for producing animals with short hair

The present invention is directed to methods of treating and/or ameliorating muscular dystrophy and/or treating cardiomyopathy in muscular dystrophy patients by administration of a therapeutically effective amount of a thromboxane Areceptor antagonist.

Compositions and methods of treating muscular dystrophy with thromboxane-Areceptor antagonists

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Disclosed are materials and methods for creating customizable traits in animals. In the demonstration of the principle of the subject invention, a keratin-14 specific promoter is used with, red fluorescent protein in the loxp cassette, dominant black (&#x394;G23) beta defensin 103 in the pigment cassette, and an SV40 (with intron) polyadenylation sequence. When Cre recombinase (or HTNCre) is applied to the animal's skin in a carrier base (e.g., lipid bilayers), fur is permanently genetically modified to turn black in the shape in which it was applied.

Transgenic animals with customizable traits

The present invention provides highly advantageous and efficient methods for spermatogonial stem cell (SSC) transfer for the generation of animals having valuable traits or genetic background.

Methods for spermatogonial stem cell (SSC) transfer

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Nashville, TN, United States of America

James West