Abbott Laboratories Corporation

James W Scheffel

Joan D Tyner

Jeffrey C Hunt

John George Konrath

Xiaoxing Qiu

Sheng C Lou

Michael White

David J Hawksworth

Robert N Ziemann

Bailin Tu

Robin A Gutierrez

Mary S Pinkus

Jeffrey M Werneke

Steven C Hodges

Charles L Nelson

Carol Mazurek

John G Konrath

The present invention relates to novel monoclonal antibodies which may be used in the detection of Human Immunodeficiency Virus (HIV). These antibodies exhibit an unusually high degree of sensitivity, a remarkably broad range of specificity, and bind to novel shared, non-cross-reactive epitopes. In particular, the monoclonal antibodies of the present invention may be utilized to detect HIV-1 antigen and HIV-2 core antigen in a patient sample.

Monoclonal antibodies to human immunodeficiency virus and uses thereof

Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnostic reagents for the detection of HCV, and/or as standardization reagents or positive control reagents in assays for the detection of HCV. The recombinant antibodies can also be used in the treatment or prevention of a HCV infection.

Recombinant antibodies against hepatitis C virus and methods of obtaining and using same

Methods for the detection of HIV-1 or -2 antigens employing monoclonal antibodies that recognize a shared HIV-1/-2 epitope in the capsid p24/p26 proteins

Monoclonal antibodies that recognize a shared epitope between the human immunodeficiency virus type 1 (HIV-1) capsid (CA/p24) and the human immunodeficiency virus type 2 (HIV-2) capsid (CA/p26)

Monoclonal antibodies that recognize a shared epitope between the human immunodeficiency virus type 1 (HIV-1) capsid (CA/p24) and the human immunodeficiency virus type 2 (HIV-2) capsid (CA/p26).

A device for particle agglutination analysis and a method for its use. The device includes means forming a longitudinally extending channel, an opening communicating from the exterior of the device to a first end of the channel, a reservoir communicating with the second end of the channel, and a vent opening communicating from the reservoir to the exterior of the apparatus. The channel has a sufficiently large cross section and the vent is positioned such that, when the channel is in a vertical position, a given amount of fluid, introduced through the opening into the channel will flow by gravity through the channel and into the reservoir, filling the channel to a desired height and the reservoir to the same height without flowing through the vent, while air escapes through the vent. Gravity causes sufficient movement of the particles so that agglutination may occur.

Device for analysis of rapid agglutination of particles and method for

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Mundelein, IL, United States of America

James W Scheffel