Lynntech, Inc.

James W Magnuson

Dalibor Hodko

Anthony Giletto

Adrain Denvir

Ryan T Hayes

Krzysztof C Kwiatkowski

John Van Hyfte

A device for the transdermal delivery of a therapeutic agent to a biological subject that includes a first electrode comprising a first array of electrically conductive microprojections for providing electrical communication through a skin portion of the subject to a second electrode comprising a second array of electrically conductive microprojections. Additionally, a reservoir for holding the therapeutic agent surrounding the first electrode and a pulse generator for providing an exponential decay pulse between the first and second electrodes may be provided. A method includes the steps of piercing a stratum corneum layer of skin with two arrays of conductive microprojections, encapsulating the therapeutic agent into biocompatible charged carriers, surrounding the conductive microprojections with the therapeutic agent, generating an exponential decay pulse between the two arrays of conductive microprojections to create a non-uniform electrical field and electrokinetically driving the therapeutic agent through the stratum corneum layer of skin.

Transdermal delivery of therapeutic agent

The present invention relates to a method of remediating soil, water, and other porous media contaminated with organic and/or inorganic contaminants using plants in conjunction with an electric field applied through the medium to control movement of the contaminants and enhance removal of the contaminants from the medium. Applying an electric field in soil induces electromigration (movement of ions in the pore fluid), as well as electroosmosis (movement of pore water) and electrophoresis (movement of charged particles in soil such as colloids). In the present invention these phenomena are beneficially utilized to control the transport of charged and/or non-charged contaminants in soil within the plant root zone (rhizosphere) and to bring contaminants into the root zone, perhaps from a contaminated zone located deeper in the soil than the root zone. The effectiveness of the phytoremediation is also enhanced by preventing the soil from becoming so strongly acidic or basic as to kill the plants. The present invention significantly extends the utility of phytoremediation to cleanup of soils with deeper contamination plumes than are typically accessible to the roots of plants.

Methods for enhancing phytoextraction of contaminants from porous media

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College Station, TX, United States of America

James W Magnuson