Auburn University

Edward Via College of Osteopathic Medicine—auburn

James W Gillespie

Alexandre M Samoylov

Kenny V Brock

Tatiana I Samoylova

Valery A Petrenko

Anna M Cochran

Deepa Bedi

Olusegun A Fagbohun

Disclosed are recombinant bacteriophage constructs and related exogenous peptide sequences for generating immune responses against CD47. The disclosed recombinant phage constructs bind to antibodies against CD47 and can be administered to an animal to generate an immune response against CD47, including generating anti-CD47 antibodies. The disclosed recombinant phage may comprise an amino acid sequence of CD47, epitopic fragments, variants, or functional mimics thereof. Also disclosed are methods for making and selecting such recombinant phage constructs and compositions that comprise such constructs (e.g., compositions for inducing an immune response against CD47 including pharmaceutical or veterinary compositions used as vaccines). Also disclosed are recombinant polynucleotides comprising genomic nucleic acid of the recombinant phage constructs disclosed herein.

Phage-peptide constructs for stimulating an immune response against CD47

Disclosed are targeted particles comprising or consisting of a plurality of landscape phage fusion proteins complexed with heterologous nucleic acid, the landscape phage fusion proteins displaying a heterologous peptide and the targeted particle binding specifically to a target site. The particles may be utilized in methods for modulating expression of genes in target cells.

Targeted particles comprising landscape phage fusion proteins and heterologous nucleic acid

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Auburn, AL, United States of America

James W Gillespie