Pharmacia & Upjohn Company

Zoetis Services LLC

James Taylor Curry

Steven Alan Dunham

E Jon Jacobsen

Andrea Joy Gonzales

Gary Francis Bammert

Donald Wayne Mann

Stephen J Humphrey

Robert B McCall

William R Humphrey

An IL-31 dog pruritus model is provided. This model comprises administering canine IL-31 to dogs to produce a pruritic response; quantitatively measuring pruritic responses in the dogs which were administered canine IL-31; administering a candidate dog IL-31 inhibitor; and assessing the effectiveness of the candidate dog IL-31 inhibitor in reducing prurtic behavior in the treated dogs by challenging the dogs with canine IL-31 following the administration of the candidate dog IL-31 inhibitor.

IL-31 dog pruritus model

A diuretic compound of Formula I ##STR1## or pharmaceutically acceptable salt thereof where R.sup.1 is a C.sub.1-6 alkyl; R.sup.2 is halogen, C.sub.1-4 alkyl; and R.sup.3 is C.sub.1-4 alkoxy are disclosed, preferably, benzamide, 3-chloro-N-(2-ethyl-2-(3-methoxyphenyl)-4-(1-piperidinyl)butyl), monohydrochloride. The compounds are effective diuretics which increase the excretion of water with little increase in electrolyte excretion.

Diuretic compound

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Kalamazoo, MI, United States of America

James Taylor Curry