Geron Corporation

Kosan Biosciences Incorporated

James T Kealey

Scott L Weinrich

Ronald A Pruzan

Daniel V Santi

Linda C Dayem

Alain Philippe Vasserot

Serge P Lichtsteiner

Edward M Atkinson, Iii

Neal I Gutterson

Nam Woo Kim

Mary C Betlach

Ed Ralston

Fred Wu

Larry Peck

This invention provides inhibitory polynucleotides, such as antisense molecules, directed against accessible regions in the telomerase ribonucleoprotein. The polynucleotides are useful for inhibiting the activity of telomerase in cells and for treating cancer.

Inhibitory polynucleotides directed against the RNA component of telomerase

Host cells, such as, are provided with an expression system for making starter units required for biosynthesis of polyketides using the ato pathway.

Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit

Recombinanthost cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase fromoras well asepimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases not present in wild-typehost cells.

Genetically modified cells and methods for converting (R)-methylmalonyl CoA to (S)-methylmalonyl CoA

Recombinanthost cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase fromoras well asepimerase can produce S-methylmalonyl CoA, a required substrate for the production of polyketides by most modular polyketide synthases and is not present in wild-typehost cells.

Heterologous production of polyketides

The present invention provides genetically altered plants and plant cells that have been modified to contain expression system(s) capable of expressing a functional polyketide synthase (PKS). The present invention further provides methods of producing PKS and polyketides using these plants and cells.

Production of polyketides in plants

This invention provides purified human telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of a first matrix that binds molecules bearing negative charges, a matrix that binds molecules bearing positive charges, a second matrix that binds molecules bearing negative charges, an affinity purification step and a matrix that separates molecules according to their size.

Purified telomerose

Purified telomerase

Methods of detecting the RNA component of telomerase, diagnosing cancer, and determining its prognosis using polynucleotides that hybridize to the RNA component of mammalian telomerase in a sample.

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San Anselmo, CA, United States of America

James T Kealey