Astrazeneca Ab

James Stewart Scott

Bernard Barlaam

Johannes Wilhelmus Maria Nissink

Bin Yang

Thomas Andrew Moss

Samantha Jayne Hughes

Daniel Hillebrand O'Donovan

Paul Robert Owen Whittamore

Martin John Packer

Andrew Stocker

William McCoull

Jeffrey Gilbert Varnes

Dedong Wu

Gary Peter Tomkinson

Dan Anders Broo

Martin Packer

William Mccoull

Paul Robert Whittamore

Bernard Christophe Barlaam

The specification relates to compounds of Formula (I): and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of cell proliferative disorders.

Chemical compounds

Selective estrogen receptor down-regulators

The specification relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

The specification relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Compounds of formula (I): wherein variable groups are defined within; their use in the inhibition of 11&#x3b2;HSD1, processes for making them and pharmaceutical compositions comprising them are described.

A compound of formula (I): and pharmaceutically-acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11&#x3b2;HSD1, processes for making them and pharmaceutical compositions comprising them are also described.

Pyrazole derivatives as 11-beta-HSD1 inhibitors

New crystalline forms of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid; their use in the inhibition of 11&#x3b2;HSD1, processes for making them and pharmaceutical compositions comprising them are also described.

Crystalline forms of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]Benzoic acid 471

Growing community of inventors

Cambridge, United Kingdom

James Stewart Scott