Emory University

The United States of America, As Represented by the Secretary, Department of Health and Human Services

James Smith

Harriet L Robinson

Bernard Moss

Rama Rao Amara

Salvatore T Butera

Dennis Ellenberger

Jian Hua

We have developed DNA and viral vectors that can be used, alone or in combination, as a vaccine against one HIV clade, subtype, or recombinant form of HIV or against multiple HIV clades, subtypes, or recombinant forms. Moreover, the vectors can encode a variety of antigens, which may be obtained from one clade or from two or more different clades, and the antigens selected and/or the manner in which the vectors are formulated (e.g., mixed) can be manipulated to generate a protective immune response against a variety of clades (e.g., the clades to which a patient is most likely to be exposed; with the proportions of the components of the vaccine tailored to the extent of the patient's risk to a particular clade or clades).

Compositions and methods for generating an immune response

Growing community of inventors

Cumming, GA, United States of America

James Smith