Second Sight Medical Products, Inc.

Other

Gambro, Inc.

Doheny Eye Institute

Second Sight Products, Inc.

James Singleton Little

Robert Jay Greenberg

Neil Hamilton Talbot

Jordan M Neysmith

Brian V Mech

Kelly Hobart McClure

Rongqing Dai

Dao Min Zhou

Kea-Tiong Tang

Mark Salman Humayun

Arup Roy

Chunhong Zhou

Sumit Yadav

David Daomin Zhou

Pishoy Maksy

John J Reinhold

Jerry Ok

Richard Agustin Castro

Rajat N Agrawal

Qingfang Yao

Da-Yu Chang

Kevin Wilkin

Boozarjomehr Faraji

Kevin Jun Ha

Alfred E Mann

Matthew J McMahon

Mark Humayan

Dilek Guven

Karl-Heinz Ihrig

DaoMin Zhou

Amy Hines

Eugene De Juan, Jr

Satinderpall Singh Pannu

James Courtney Davidson

Alain Frugier

Phillipe John Tabada

Mark S Humayun

Mohamed Khaldi

Jean-Louis Fressinet

David B Greene

Boon-Khai Ng

Jianing Wei

Jordan Matthew Nevsmith

Gaillard R Nolan

Anne Marie Ripley

Melody Tabada, Legal Representative

Laquita Worley

Richard Augustin Castro

Anne-Marie De Merlier Ripley

Kelly H Mcclure

Jordan Matthew Neysmith

Kelly Mcclure

Yao Qingfang

David Daomin Zouh

Neil Hamiton Talbot

A temperature controlled storage device for storing food and beverages includes a shell, which defines an interior space and is resiliently flexible. The shell comprises an inner layer and an outer layer that define an internal space, to which addition of air selectively inflates the shell from a collapsed configuration to a semirigid configuration. A top of the shell is reversibly couplable to opposing sides and a front of the shell so that the top is hingable relative to a back of the shell to allow access to the interior space. A closure that extends between the top of the shell and both the opposing sides and the front of the shell is positioned to selectively couple the top to the shell. A temperature control module that is coupled to and positioned in the shell selectively warms and cools the interior space and contents thereof.

Temperature controlled storage device

In electrically stimulating neural tissue it is important to prevent over stimulation and unbalanced stimulation, which would cause damage to the neural tissue, the electrode, or both. It is critical that neural tissue is not subjected to any direct current or alternating current above a safe threshold. Further, it is important to identify defective electrodes, as continued use may result in neural damage and further electrode damage. The present invention presents system and stimulator control mechanisms to prevent damage to neural tissue.

Method and apparatus to provide safety checks for neural stimulation

Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.

Flexible circuit electrode array

An implantable device having a biocompatible hermetic package made from a biocompatible electrically non-conductive substrate and a cover bonded to the substrate. In integrated circuit and passive circuits all bonded directly to the substrate.

Package for an implantable neural stimulation device

In electrically stimulating neural tissue it is important to prevent over stimulation and unbalanced stimulation which would cause damage to the neural tissue, the electrode, or both. It is critical that neural tissue is not subjected to any direct current or alternating current above a safe threshold. Further, it is important to identify defective electrodes as continued use may result in neural damage and further electrode damage. The present invention presents system and stimulator control mechanisms to prevent damage to neural tissue.

A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on the polymer base layer and the metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.

The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad. The disclosure further relates to a method of making a flexible circuit electrode array comprising: depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array, embedding a support at least in the base layer, top layer or between the base and top layer, and/or folding a flexible circuit cable at least once connecting the electrode array with an interconnection pad on the array.

Flexible circuit electrode array with wire or film support

The present invention is a flexible circuit electrode array with a polymer base layer, metal traces deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue, a polymer top layer deposited on the polymer base layer and the metal traces, and a soft polymer filling a void through both the polymer base layer and polymer top layer, the soft polymer forming drum stress relief around an attachment point.

Flexible circuit electrode array with a drum stress relief

The present invention provides an implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material. The present invention further provides a method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer.

Electrode with increased stability and method of manufacturing the same

The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on the polymer base layer and the metal traces at least one tack opening. The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on the polymer base layer; patterning the metal to form metal traces; depositing a polymer top layer on the polymer base layer and the metal traces; and preparing at least one tack opening.

Flexible circuit electrode array with at least one tack opening

An apparatus for controlling the stimulation of neural tissue which includes a neural stimulator, an input device for providing input to the neural stimulator for neural stimulation, at least one electrode electrically connected to and driven by the neural stimulator and suitable to stimulate neural tissue, a device capable of determining a charge per phase by calculating a discrete integral of the wave form of the input for the at least one electrode, a calculating device for comparing the charge per phase to a predetermined maximum and determining a reduced stimulation for the at least one electrode by the amount necessary not to exceed the predetermined maximum for the at least one electrode, and a current pulse generator for stimulating the neural tissue according to the reduced stimulation level.

The present invention consists of an implantable device with at least one package that houses electronics that sends and receives data or signals, and optionally power, from an external system through at least one coil attached to at least one package and processes the data, including recordings of neural activity, and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that are attached to the at least one package. The device is adapted to electrocorticographic (ECoG) and local field potential (LFP) signals. A brain stimulator, preferably a deep brain stimulator, stimulates the brain in response to neural recordings in a closed feedback loop. The device is advantageous in providing neuromodulation therapies for neurological disorders such as chronic pain, post traumatic stress disorder (PTSD), major depression, or similar disorders. The invention and components thereof are intended to be installed in the head, or on or in the cranium or on the dura, or on or in the brain.

Cortical implant system for brain stimulation and recording

Growing community of inventors

Arvada, CO, United States of America

James Singleton Little