The University of Tennessee Research Foundation

Attralus, Inc.

Other

James S Foster

Jonathan Wall

Spencer Guthrie

Stephen J Kennel

Jaume Pons

Michael L Klein

Brian K Muchmore

Provided herein are modified immunoglobulins comprising an amyloid reactive peptide joined to an antibody, as well as humanized antibodies that bind to human amyloid fibrils and antibody-peptide fusion proteins. Also provided herein are methods of treating amyloid-based diseases by administering a modified immunoglobulin, humanized antibody, or antibody-peptide fusion protein.

Modified immunoglobulins for targeting amyloid deposits

Provided herein are antibody-peptide fusion proteins comprising an amyloid-reactive peptide linked to an antibody. Also provided herein are methods of treating amyloid-based diseases by administering an antibody-peptide fusion protein.

Antibody-peptide fusion proteins for treating amyloid disorders

Disclosed are methods and compositions for targeting antibodies to amyloid deposits. For example, amyloid-reactive peptides that bind amyloid deposits are administered to a subject. Antibodies to the amyloid-reactive peptides are then administered to the subject. Upon administration of the antibodies, the amyloid-reactive peptides bind the antibodies and thus pre-target the antibodies to the amyloid deposits. In other examples, an amyloid-reactive fusion peptide contains an epitope of a known antibody. When the fusion peptide is administered to a subject, the fusion peptide binds amyloids in the subject. Administration to the subject of the known antibody that binds the epitope of the fusion peptide then targets the antibody to the amyloid deposit to which the fusion peptide is bound.

Targeting immunotherapy for amyloidosis

A light-weight turf conditioning machine provides programmable subterranean soil processing. The machine includes a set of electronically controlled air guns that are mounted on a frame a given distance above the ground. Each air gun disperses a high pressure stream of fluid into the ground in a vertically aligned cylindrical shape drilling holes into a golf green. The holes are drilled using a hydrated polymer that absorbs and releases moisture in a controlled fashion fostering plant growth. A programmable controls circuit controls the rate, pattern and depth in which holes are drilled into a golf green. A portable storage tank is fluidly joined by a hose to the air guns. The hose allows the storage tank to spaced from the machine as the air guns are carried over the golf green.

Growing community of inventors

Knoxville, TN, United States of America

James S Foster