Pharmacyclics, Inc.

Millennium Pharmaceuticals Limited

Aerojet Fine Chemicals LLC

Ampac Fine Chemicals LLC

Tapp Technologies, LLC

James Robinson

Joseph J Buggy

Martin Sendzik

Chitra Baskaran

Erik J Verner

Robert M Scarborough

Anjali Pandey

Aslam A Malik

James P Kanter

Hasan Palandoken

Joy A Stringer

Todd E Clement

Joseph M Callahan

Carroll Scarborough, Legal Representative

Eric J Verner

James Kanter

A system configured to manage the distribution of content to one or more cooperating media/substrates in beverage dispensing environments, wherein the system receives data representative of environment conditions for one or more cooperating media/substrates adapted to display digital content, where the media/substrates may be located in beverage environments (e.g., bar/restaurants, hotels, or event venues), and where the system compares the received data representative of environment conditions regarding the purchase of a beverage with selection criteria to identify content for distribution to the media/substrates such that the selected content is distributed to the one or more cooperating media/substrates.

Content distribution platform for beverage dispensing environments

The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase activity. Pharmaceutical compositions and processes for preparing these compounds are also disclosed.

Hydroxamates as therapeutic agents

The present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof and a process for making thereof. The compounds have inhibitory activity on the phosphorylation of kinases, which inhibits the activity of such kinases. The invention also provides intermediate compounds useful in the process, as well as final products produced by the process, and salts or prodrugs thereof. The invention further provides a method of inhibiting kinases and treating disease states in a mammal by inhibiting the phosphorylation of kinases comprising administering an effective amount of a compound according to the invention to a patient in need thereof.

Nitrogenous heterocyclic compounds and process for making nitrogenous heterocyclic compounds and intermediates thereof

The present invention provides compounds and methods that can be used to convert the intermediate halomethyl ketones (HMKs), e.g., chloromethyl ketones, to the corresponding S,S- and R,S-diastereomers. More particularly, the present invention provides: (1) reduction methods; (2) inversion methods; and (3) methods involving the epoxidation of alkenes. Using the various methods of the present invention, the R,S-epoxide and the intermediary compounds can be prepared reliably, in high yields and in high purity.

Clean, high-yield preparation of S,S and R,S amino acid isosteres

The present invention provides compounds and methods that can be used to convert the intermmediate halomethyl ketones (HMKs), e.g., chloromethyl ketones, to the corresponding S,S- and R,S-diastereomers. More particularly, the present invention provides: (1) reduction methods; (2) inversion methods; and (3) methods involving the epoxidation of alkenes. Using the various methods of the present invention, the R,S-epoxide and the intermediary compounds can be prepared reliably, in high yields and in high purity.

Clean, High-yield preparation of S,S and R,S amino acid isosteres

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Sacramento, CA, United States of America

James Robinson